Electrochemical selenium–π–acid promoted hydration of alkynyl phosphonates. Issue 54 (16th June 2022) - Li, Bo
Abstract : Unprecedented electrochemical selenium–π–acid promoted hydration of alkynes bearing a phosphonate auxiliary was described. Thus, valuable (hetero)aryl and alkyl ketones could be accessed under mild, metal- and external oxidant-free conditions. Abstract : An unprecedented electrochemical selenium–π–acid promoted hydration of internal alkynes bearing a phosphonate auxiliary was described. Thus, valuable (hetero)aryl and alkyl ketones could be accessed under mild, metal- and external oxidant-free conditions. This protocol features high atom-economy, good chemo- and regio-selectivity, excellent functional group tolerance and easily transformable products. Control experiments demonstrate that phosphonate assistance is essential for this transformation.