Iodine(iii) reagents for oxidative aromatic halogenation. Issue 25 (15th June 2022)

• Record Type: Journal Article
• Authors: Segura-Quezada, Luis A.; Torres-Carbajal, Karina R.; Juárez-Ornelas, Kevin A.; Alonso-Castro, Angel J.; Ortiz-Alvarado, Rafael; Dohi, Toshifumi; Solorio-Alvarado, César R.
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 25(2022)
• Page Start: 5009
• Page End: 5034
• Publication Date: 2022-06-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00741j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Iodine(iii ) reagents have attracted chemical importance in organic synthesis by their use as safe, non-toxic, green and easy to handle reagents in different transformations. Abstract : Iodine(iii ) reagents have attracted chemical relvance in organic synthesis by their use as safe, non-toxic, green and easy to handle reagents in different transformations. These characteristics make them important alternatives to procedures involving hazardous and harsh reaction conditions. Their versatility as oxidants has been exploited in the functionalization of different aromatic cores, which allow the introduction of several groups. Metal-free arylation using iodine(iii ) reagents is by far one of the most described topics in the literature; however, other highly relevant non-aromatic groups have been also introduced. Herein, we summarize the most representative developed procedures for the functionalization of aryls and heteroaryls by introducing halogens, using different iodine(iii ) reagents.