Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease. (12th April 2022)

• Record Type: Journal Article
• Authors: Dedrick, Rebekah M; Freeman, Krista G; Nguyen, Jan A; Bahadirli-Talbott, Asli; Cardin, Mitchell E; Cristinziano, Madison; Smith, Bailey E; Jeong, Soowan; Ignatius, Elisa H; Lin, Cheng Ting; Cohen, Keira A; Hatfull, Graham F
• Is Part Of: Open forum infectious diseases. Volume 9:Number 7(2022)
• Publication Date: 2022-04-12
• Subjects: Mycobacterium abscessus -- bacteriophage -- mycobacteriophage -- phage therapy; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac194
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.