Salvage debulking surgery and hyperthermic intrathoracic chemotherapy for massive recurrent mesothelioma in the mediastinum. (26th February 2022)

• Record Type: Journal Article
• Authors: Poon, Shi Sum; Alberti, Caterina; Nardini, Marco; Migliore, Marcello
• Is Part Of: Interactive cardiovascular and thoracic surgery. Volume 35:Number 1(2022)
• Publication Date: 2022-02-26
• Subjects: Mesothelioma -- Debulking surgery -- Hyperthermic intrathoracic chemotherapy -- Pleurectomy -- Decortication; Chest -- Surgery -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.1
• DOI: 10.1093/icvts/ivac034
• Languages: English
• ISSNs: 1569-9293

Abstract

Abstract: Mediastinal malignant pleural mesothelioma with signs of tamponade is rare. Indication for reoperation for recurrent malignant pleural mesothelioma is a controversial but viable option in selected patients. We report a case of a 68-year-old man presenting with epithelioid malignant pleural mesothelioma who underwent a total of three debulking surgeries (pleurectomy/decortication) combined with hyperthermic intrathoracic chemotherapy. Five years after the first procedure, a third urgent operation was performed for recurrence of a large mediastinal mesothelioma causing acute symptoms of pericardial constriction and tamponade. The patient was alive for eight years since the first treatment and 36 months after the second reoperation. Abstract : A 68-year-old Caucasian man, ex-smoker, with history of ischaemic heart disease, was diagnosed with left epithelioid malignant pleural mesothelioma (MPM) in March 2013.