Transapical beating heart mitral valve repair versus conventional surgery: a propensity-matched study. (2nd March 2022)

• Record Type: Journal Article
• Authors: D'Onofrio, A; Mastro, F; Nadali, M; Fiocco, A; Pittarello, D; Aruta, P; Evangelista, G; Lorenzoni, G; Gregori, D; Gerosa, G
• Is Part Of: Interactive cardiovascular and thoracic surgery. Volume 35:Number 1(2022)
• Publication Date: 2022-03-02
• Subjects: Mitral valve repair -- Surgical -- Mitral valve repair -- Transapical; Chest -- Surgery -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.1
• DOI: 10.1093/icvts/ivac053
• Languages: English
• ISSNs: 1569-9293

Abstract

Abstract: OBJECTIVES: Transapical Neochordae implantation (NC) allows beating heart mitral valve repair in patients with degenerative mitral regurgitation. The aim of this single-centre, retrospective study was to compare outcomes of NC versus conventional surgical (CS) mitral valve repair. METHODS: Data of patients who underwent isolated mitral valve repair with NC or CS from January 2010 to December 2018 were collected. A propensity score matching analysis was performed to reduce confounding due to baseline differences between groups. The primary end point was overall all-cause mortality; secondary end points were freedom from reoperation, freedom from moderate (2+) and from severe (3+) mitral regurgitation (MR) and New York Heart Association functional class in the overall population and in patients with isolated P2 prolapse (type A anatomy). RESULTS: Propensity analysis selected 88 matched pairs. There was no 30-day mortality in the 2 groups. Kaplan–Meier analysis showed similar 5-year survival in the 2 groups. Patients undergoing NC showed worse freedom from moderate MR (≥2+) (57.6% vs 84.6%; P < 0.001) and from severe MR (3+) at 5-year follow-up: 78.1% vs 89.7% ( P = 0.032). In patients with type A anatomy, freedom from moderate MR and from severe MR was similar between groups (moderate: 63.9% vs 74.6%; P = 0.21; severe: 79.3% vs 79%; P = 0.77 in NC and FS, respectively). Freedom from reoperation was lower in the NC group: 78.9% vs 92% ( P = 0.022) but, in type A patients, it was similar: 79.7% and 85% ( P = 0.75) in the NC and CS group, respectively. More than 90% of patients of both groups were in New York Heart Association class I and II at follow-up. CONCLUSIONS: Transapical beating-heart mitral chordae implantation can be considered as an alternative treatment to CS, especially in patients with isolated P2 prolapse Abstract : Surgical mitral valve repair is the gold standard treatment for degenerative mitral regurgitation (DMR), since it provides excellent long-term clinical and echocardiographic results and it is currently recommended by guidelines [1–11].