Arterial hypertension and morphologic abnormalities of cardiac chambers: results from the Copenhagen General Population Study. Issue 4 (24th April 2021)

• Record Type: Journal Article
• Authors: Fuchs, Andreas; Kühl, J. Tobias; Sigvardsen, Per E.; Knudsen, Andreas D.; Nilsson, Emma Julia P.; Stisen, Zara R.; Jeppesen, Jørgen L.; Nordestgaard, Børge G.; Køber, Lars V.; Kofoed, Klaus F.
• Is Part Of: Journal of hypertension. Volume 39:Issue 4(2021)
• Page Start: 703
• Page End: 710
• Publication Date: 2021-04-24
• Subjects: general population study -- hypertension -- left atrial volume -- left ventricular mass -- morphologic abnormalities of cardiac chambers; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000002705
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Supplemental Digital Content is available in the text Abstract : Objectives: In patients with arterial hypertension (AH), hypertension-mediated organ damage may be manifested by cardiac chamber enlargement and/or remodeling. Cardiac computed tomography imaging has emerged as an important method for morphological assessment of cardiac chambers. We tested the hypothesis that prevalence of cardiac chamber abnormalities is specifically related to clinical categories of AH in the general population. Methods: We studied 4747 individuals, mean age was 60 years (range: 40–93), 46% were men, undergoing 320-detector computed tomography in the Copenhagen General Population Study. Clinical categories of AH were: normotensive ( n = 2484), untreated hypertensive ( n = 1301), treated controlled hypertensive ( n = 412) and treated uncontrolled hypertensive ( n = 550). Chamber abnormalities in the form of left ventricular (LV) concentric remodeling, LV eccentric hypertrophy, LV concentric hypertrophy or left atrial enlargement were assessed, in addition to LV or right ventricular enlargement. Results: Chamber abnormalities were present in 23% of all individuals. Combined LV and left atrial abnormalities were rare (<2%). LV concentric remodeling (10%) was the most prevalent abnormality, and most commonly found in individuals with treated hypertension. LV and right ventricular enlargements were unrelated to hypertension. The highest frequencies of chamber abnormalities were found in individuals of elevated blood pressure (BP) with (40%) or without (32%) treatment, as opposed to individuals of normal BP with (27%) or without (14%) treatment, P less than 0.0001. Conclusion: In a general population cohort, untreated or inadequately treated AH was associated with the highest prevalence of cardiac chamber enlargement and remodeling. These observations suggest a strong link between elevated BPs and development of hypertension-mediated organ damage.