18F-FDG Brain PET Findings in Narcolepsy Type 2. (19th August 2022)

• Record Type: Journal Article
• Authors: Varughese, Robin T.; Kothare, Sanjeev V.; Franceschi, Ana Marija
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 8(2022)
• Page Start: e559
• Page End: e561
• Publication Date: 2022-08-19
• Subjects: 18F-FDG -- PET -- sleep disorder -- rapid eye movement -- REM -- narcolepsy; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004264
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: A 16-year-old adolescent boy with extensive travel throughout West Africa presented with a 6-year history of social withdrawal, anhedonia, and daytime sleepiness. The patient's electroencephalography was normal. Initial MRI revealed small pituitary gland and left temporal developmental venous anomaly. Subsequently obtained 18 F-FDG brain PET was notable for markedly severe hypometabolism in the brainstem. Further workup revealed a normal orexin, autoimmune encephalitis panel, and negative titers for Trypanosoma brucei and cruzi in the CSF. Outpatient sleep study showed mild obstructive sleep apnea, and multiple sleep latency test revealed reduced mean sleep latency at 7 minutes with sleep-onset REM in 3/5 naps, findings consistent with narcolepsy type 2.