Cytokines and Chemokines Modulation of Itch. (15th July 2022)

• Record Type: Journal Article
• Authors: Du, Li-Xia; Zhu, Jian-Yu; Mi, Wen-Li
• Is Part Of: Neuroscience. Volume 495(2022)
• Page Start: 74
• Page End: 85
• Publication Date: 2022-07-15
• Subjects: ACD allergic contact dermatitis -- AD atopic dermatitis -- AEW acetone, diethyl ether, and water -- CCL1 chemokine (C–C motif) ligand 1 -- CCL2 chemokine (C–C motif) ligand 2 -- CCR2 C–C chemokine receptor 2 -- CSU chronic spontaneous urticaria -- CTCL cutaneous T-cell lymphoma -- CX3CL1 chemokine (C–X3–C motif) ligand 1 -- CX3CR1 C–X3–C receptor 1 -- CXCL1 chemokine (C–X–C motif) ligand 1 -- CXCL10 chemokine (C–X–C motif) ligand 10 -- CXCR3 C–X–C receptor 3 -- DCP diphenylcyclopropenone -- DNCB 2, 4-dinitrochlorobenzene -- DNFB 2, 4-dinitrofluorobenzene -- DRG dorsal root ganglion -- GRP gastrin-releasing peptide -- HDMs house dust mites -- IL interleukin -- IL-2R IL-2 receptor -- IL-31RA IL-31 receptor A -- JAK janus kinase -- JAK2 janus kinase 2 -- LCN2 lipocalin-2 -- Mrgpr Mas-related G protein-coupled receptor -- Muse multilineage-differentiating stress-enduring -- OSMR oncostatin M receptor -- PAR protease-activated receptor -- rIL-33 recombinant IL-33 -- SADBE squaric acid dibutylester -- STAT3 signal transducer and activator of transcription 3 -- Th2 T-helper 2 -- TNF-α tumor necrosis factor-alpha -- TNFR TNF receptor -- TRPA1 transient receptor potential ankyrin 1 -- TRPV1 transient receptor potential vanilloid 1 -- TSLP thymic stromal lymphopoietin; itch -- cytokines -- chemokines -- skin diseases -- neuromodulators; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2022.05.035
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Cytokines participant in the pathogenesis of itch in both human and rodents. Some cytokines directly activate sensory neurons and act as pruritogens. Chemokines modulate pathogenesis of itch in the peripheral and central level. Abstract: Itch (pruritus) is a common cutaneous symptom widely associated with many skin complaints, and chronic itch can be a severe clinical problem. The onset and perpetuation of itch are linked to cytokines, such as interleukin (IL)-31, IL-4, IL-13, IL-33, thymic stromal lymphopoietin, and tumor necrosis factor-alpha, and chemokines, such as chemokine (C–C motif) ligand 2 and C–X–C motif chemokine ligand 10. This review highlights research that has attempted to determine the attributes of various cytokines and chemokines concerning the development and modulation of itch. Through such research, clinical approaches targeting cytokines and/or chemokines may arise, which may further the development of itch therapeutics.