Coexistence of sensory qualities and value representations in human orbitofrontal cortex. (July 2022)

• Record Type: Journal Article
• Authors: Yoshimoto, Takaaki; Okazaki, Shuntaro; Sumiya, Motofumi; Takahashi, Haruka K.; Nakagawa, Eri; Koike, Takahiko; Kitada, Ryo; Okamoto, Shiki; Nakata, Masanori; Yada, Toshihiko; Kosaka, Hirotaka; Sadato, Norihiro; Chikazoe, Junichi
• Is Part Of: Neuroscience research. Volume 180(2022)
• Page Start: 48
• Page End: 57
• Publication Date: 2022-07
• Subjects: Functional MRI -- Gustatory experience -- Human -- Multivoxel pattern analysis -- Reward; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2022.02.004
• Languages: English
• ISSNs: 0168-0102

Abstract

Abstract: Despite the multiple regions and neural networks associated with value-based decision-making, the orbitofrontal cortex (OFC) is possible a particularly important one. Although the role of the OFC in reinforcer devaluation tasks, which assess the ability to represent identity, sensory qualities, and subjective values of the expected outcomes, has been established, the specific aspect represented in this area remains unclear. In this study, using functional magnetic resonance imaging, wherein participants rated the palatability of 128 food items using photographs, we investigated whether the human OFC represents object identity, sensory qualities, or value. Employing many items helped us dissociate object identity from sensory qualities and values; the inferred sensory qualities of identical items were manipulated by a change in metabolic state. Moreover, value differences between items were analytically controlled by employing a technique similar to age adjustment. The palatability ratings for food items significantly decreased after a meal. Using representational similarity analysis, we confirmed that the OFC represents value. Moreover, identical items were represented similarly in the lateral OFC in a given metabolic state; however, these representations were altered post-feeding. Importantly, this change was not explained by subjective value, suggesting that the OFC represents sensory quality and value, but not object identity. Highlights: We investigated the state-dependent/independent representations of human OFC. OFC represents the subjective values for food photos. Representation of identical food objects in the lateral OFC is altered by feeding. The state-dependent changes in OFC representations are not explained by value. Lateral OFC represents sensory qualities and subjective value.