Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy. Issue 6 (June 2022)

• Record Type: Journal Article
• Authors: Zhang, Wenjie; Taheri-Ledari, Reza; Ganjali, Fatemeh; Afruzi, Fereshte Hassanzadeh; Hajizadeh, Zoleikha; Saeidirad, Mahdi; Qazi, Fateme Sadat; Kashtiaray, Amir; Sehat, Samin Sadat; Hamblin, Michael R.; Maleki, Ali
• Is Part Of: Heliyon. Volume 8:Issue 6(2022)
• Publication Date: 2022-06
• Subjects: Biotechnology -- Ligands for molecular recognition -- Targeted cancer therapy -- Synergistic therapeutic effects -- High-tech nanostructures -- Nanotechnology; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2022.e09577
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles. Graphical abstract: Image 1 Highlights: Recent developments in the field of drug delivery systems is reviewed. A logical classification for the nano-sized porous materials is submitted. Conjugated proteins to the surface of nano-carriers are investigated. Protein engineering for preparation of modern drug carriers is reviewed. Nano-bioconjugates as state-of-the-art in selective cancer therapy are discussed. Abstract : Biotechnology; Ligands for molecular recognition; Targeted cancer therapy; Synergistic therapeutic effects; High-tech nanostructures; Nanotechnology.