CpG-ODN formulated with a nanostructure as adjuvant for anticrotalic serum production. Studies in mice. (August 2022)

• Record Type: Journal Article
• Authors: Fusco, Luciano S.; Pascual, María M.; Hernandez, David; Vallecillo, María F. Sánchez; Arrieta, María B.; Moron, Gabriel; Palma, Santiago; Maletto, Belkys A.; Leiva, Laura C.
• Is Part Of: Toxicon. Volume 215(2022)
• Page Start: 28
• Page End: 36
• Publication Date: 2022-08
• Subjects: C.d.terrificus venom -- CpG-ODN Adjuvant -- Ascorbyl palmitate -- Coa-ASC16; ASC16: 6-O-ascorbyl palmitate (Ascorbyl palmitate) -- CpG-ODN: oligodeoxynucleotides containing unmethylated CpG motifs; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2022.05.045
• Languages: English
• ISSNs: 0041-0101

Abstract

Graphical abstract: Image 1 Highlights: C. d. terrificus venom and CpG-ODN formulated as a liquid crystal is presented. Mice immunized with CdtV/CpG-ODN/Coa-ASC16 elicited a potent humoral response. CpG-ODN was essential to generate CdtV specific antibodies. CdtV/CpG-ODN/Coa-ASC16 shown absence of tissue lesions. CdtV/CpG-ODN/Coa-ASC16 adjuvant generate neutralizing antibodies.