A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement. (2022)

• Record Type: Journal Article
• Authors: Papanastasiou, Labrini; Skarakis, Nikitas; Vardaka, Maria; Dimitriadi, Anastasia; Lampropoulou, Pinelopi; Perpinia, Anastasia; Vidalakis, Eleftherios; Choreftaki, Theodosia; Marinakis, Theodoros; Kounadi, Theodora; Vatalas, Ioannis-Anastasios; Michalis, Eurydiki
• Is Part Of: Leukemia research reports. Volume 17(2022)
• Publication Date: 2022
• Subjects: Non-hodgkin's lymphoma -- Cardiac lymphoma -- Adrenal lymphoma -- Diffuse large b-cell non-hodgkin lymphoma; PCL primary cardiac lymphoma; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2022.100318
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome.