A new approach in acute myeloid leukemia (AML): Samatya-predicting score. (2022)

• Record Type: Journal Article
• Authors: Serin, Istemi; Orhan, Bagnu; Sonmez, Derya; Cinli, Tahir Alper; Goze, Hasan; Serin, Huriye; Gulesir, Begum; Yokus, Osman
• Is Part Of: Leukemia research reports. Volume 17(2022)
• Publication Date: 2022
• Subjects: Acute myeloid leukemia -- Flow cytometry -- Response -- Prognosis; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2022.100293
• Languages: English
• ISSNs: 2213-0489

Abstract

Highlights: We aimed to examine the efficiency of our new scoring system in non-APL AML cases, . The AUC for the median risk score of 2, 5 in ROC analysis was 0, 635 ( p = 0, 006) for exitus; 0, 605 ( p = 0, 024) for being responder, . The sensitivity for mortality was 88%, the specificity 42%, the PPV 90, 1%, and the NPV was 24, 7%, . In terms of being non-responder to induction therapy, the sensitivity was 90, 1%, the specificity 25, 3%, the PPV 89, 8%, and the NPV was 32%. Abstract: We aimed to examine the efficiency for prediction of prognosis and response in non-APL AML cases of the "Samatya-predicting score". A total of 213 patients diagnosed between January 2010-December 2020 were examined. Of the 158 patients included in the study, the median value of risk score was determined as 2, 5. The sensitivity for mortality was 88% and the specificity was 42%. In terms of being non-responder to induction therapy, the sensitivity was 90, 1%, the specificity was 25, 3%. OS was shorter in those with high risk scores. This study makes an important contribution to the literature in terms of creating a different perspective to predict prognosis in AML.