Can Cognitive training Reignite Compensatory Mechanisms in Advanced Multiple Sclerosis Patients? An Explorative Morphological Network Approach. (15th July 2022)

• Record Type: Journal Article
• Authors: Frieske, Joana; Pareto, Deborah; García-Vidal, Aran; Cuypers, Koen; Meesen, Raf L.J.; Alonso, Juli; Arévalo, Maria Jesus; Galán, Ingrid; Renom, Marta; Vidal-Jordana, Ángela; Auger, Cristina; Montalban, Xavier; Rovira, Àlex; Sastre-Garriga, Jaume
• Is Part Of: Neuroscience. Volume 495(2022)
• Page Start: 86
• Page End: 96
• Publication Date: 2022-07-15
• Subjects: BC betweenness centrality -- Cl clustering -- CR cognitive rehabilitation -- D degree -- DMN default mode network -- DS digit span -- DTI diffusion tensor imaging -- EDSS expanded disability status scale -- fMRI functional Magnetic Resonance Imaging -- HC healthy controls -- MRI magnetic resonance imaging -- MS multiple sclerosis -- PASAT paced auditory serial addition test -- PL path length -- PPMS primary progressive multiple sclerosis -- PwMS persons with multiple sclerosis -- RALT-DR Rey's Auditory Learning Test Delayed Recall -- ROI regions of interest -- RRMS relapsing-remitting multiple sclerosis -- SDMT symbol digit modalities test -- SPMS secondary progressive multiple sclerosis -- SW small world -- TAP test for attentional performance -- TMTA Trail Making Test A -- TMTB Trail Making Test B; MS -- grey matter networks -- connectivity -- cognitive rehabilitation -- MRI; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2022.03.031
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Cognitive rehabilitation might induce reorganization of grey matter networks in MS. Local brain efficiency was improved after a 5-week cognitive intervention program. Graph analysis can provide an important tool to explore pathological connectivity. Abstract: Multiple Sclerosis (MS) has been shown to significantly impair brain connectivity, as alterations in functional and structural networks have been identified and associated with clinical status, particularly cognitive deficits. We aimed to identify structural connectivity changes in grey matter networks following cognitive rehabilitation (CR) in persons with MS (PwMS). Fifteen long-standing PwMS underwent a 5-week CR-program and five healthy controls (HC) were also investigated. T1-weighted MRI scans and neuropsychological tests were obtained before and after CR. T1-weighted scans were used to examine grey matter networks with graph analytic parameters [betweenness centrality (BC), degree (D), clustering (Cl), path length (PL) and small world properties: connectedness, gamma and lambda values]. Results were analysed at the whole brain level and for each brain lobe. Before CR, PwMS displayed lower values for D in the left parietal lobe ( p = 0.009) compared to HC. After CR, significant increases in Cl located in frontal ( p = 0.024) and temporal ( p = 0.026) regions in PwMS were accompanied by significant decreases in PL located in the right parietal lobe ( p = 0.025) and BC globally ( p = 0.010). Overall, CR may prevent a network worsening in long-standing PwMS by increasing local efficiency of the brain and therefore facilitating compensation mechanisms.