Effects of reduced sedentary time on cardiometabolic health in adults with metabolic syndrome: A three-month randomized controlled trial. Issue 7 (July 2022)

• Record Type: Journal Article
• Authors: Garthwaite, Taru; Sjöros, Tanja; Laine, Saara; Vähä-Ypyä, Henri; Löyttyniemi, Eliisa; Sievänen, Harri; Houttu, Noora; Laitinen, Kirsi; Kalliokoski, Kari; Vasankari, Tommi; Knuuti, Juhani; Heinonen, Ilkka
• Is Part Of: Journal of science and medicine in sport. Volume 25:Issue 7(2022)
• Page Start: 579
• Page End: 585
• Publication Date: 2022-07
• Subjects: ALT alanine aminotransferase -- APE angle for postural estimation -- AST aspartate aminotransferase -- BP blood pressure -- CON control group -- DBP diastolic blood pressure -- FFM fat free mass -- GGT γ-glutamyltransferase -- HOMA-IR homeostatic model assessment of insulin resistance -- INT intervention group -- LPA light-intensity physical activity -- MAD mean amplitude deviation -- MET metabolic equivalent -- MetS metabolic syndrome -- MVPA moderate-to-vigorous physical activity -- PA physical activity -- SB sedentary behavior -- SBP systolic blood pressure -- WC waist circumference; Sedentary behavior -- Physical activity -- Cardiovascular risk factors -- Metabolic syndrome; Sports sciences -- Periodicals; Sports medicine -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports -- physiology -- Periodicals; Sports Medicine -- Periodicals; Sportgeneeskunde; 617.102705
• DOI: 10.1016/j.jsams.2022.04.002
• Languages: English
• ISSNs: 1440-2440

Abstract

Abstract: Objectives: To investigate if reducing sedentary behavior improves cardiometabolic biomarkers in adults with metabolic syndrome. Design: Randomized controlled trial. Methods: Sixty-four sedentary middle-aged adults with metabolic syndrome were randomized into intervention (INT; n = 33) and control (CON; n = 31) groups. INT was guided to limit sedentary behavior by 1 h/day through increased standing and light-intensity physical activity. CON was instructed to maintain usual habits. Sedentary behavior, breaks in sedentary behavior, standing, and physical activity were measured with hip-worn accelerometers for three months. Fasting blood sampling and measurements of anthropometrics, body composition, and blood pressure were performed at baseline and at three months. Linear mixed models were used for statistical analyses. Results: INT reduced sedentary behavior by 50 (95% CI: 24, 73) min/day by increasing light-intensity and moderate-to-vigorous physical activity (19 [8, 30] and 24 [14, 34] min/day, respectively). Standing increased also, but non-significantly (6 [−11, 23] min/day). CON maintained baseline activity levels. Significant intervention effects favoring INT occurred in fasting insulin (INT: 83.4 [68.7, 101.2] vs. CON: 102.0 [83.3, 125.0] pmol/l at three months), insulin resistance (HOMA-IR; 3.2 [2.6, 3.9] vs. 4.0 [3.2, 4.9]), HbA1c (37 [36, 38] vs. 38 [37, 39] mmol/mol), and liver enzyme alanine aminotransferase (28 [24, 33] vs. 33 [28, 38] U/l). Conclusions: Reducing sedentary behavior by 50 min/day and increasing light-intensity and moderate-to-vigorous activity showed benefits in several cardiometabolic biomarkers in adults with metabolic syndrome. Replacing some of the daily sedentary behavior with light-intensity and moderate-to-vigorous physical activity may help in cardiometabolic disease prevention in risk populations.