A rare case of B-lymphoid blast phase of chronic myeloid leukemia: Diagnostic challenges. (2022)

• Record Type: Journal Article
• Authors: Naiyer, Nada; Zaslav, Ann-Leslie; Ahmed, Tahmeena; Spitzer, Silvia; Ma, Yupo; Ponce, Roxanna; Lee, Htien; Lin, Hong
• Is Part Of: Leukemia research reports. Volume 17(2022)
• Publication Date: 2022
• Subjects: Acute lymphoblastic leukemia -- BCR-ABL1 -- Chronic myeloid leukemia -- CML blast phase -- Cytogenetics -- Flow cytometry; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2022.100327
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: Chronic myeloid leukemia(CML) is characterized by Philadelphia(Ph) chromosome. About 5% of cases are diagnosed in blast phase. We report a case of a 53-year-old female with no significant medical history, in B-lymphoblast crisis. Flow cytometry demonstrated B-lymphoblasts with no myeloid aberrancies, together with immature neutrophils in blood, and B-lymphoblasts in bone marrow. Cytogenetic studies identified Ph+ with complex abnormalities. Molecular analysis showed positive both for p210 and p190 transcripts in blood. ABL1 mutation analysis by Next Generation Sequencing(NGS) detected Thr315Ile mutation, which confers resistance to many tyrosine kinase inhibitors(TKIs). Eight months later she received allogeneic transplant and is doing well.