Ciliary dynein arms: Cytoplasmic preassembly, intraflagellar transport, and axonemal docking. Issue 6 (6th February 2022)

• Record Type: Journal Article
• Authors: Qiu, Tao; Roy, Sudipto
• Other Names: Zhao Chengtian guestEditor.; Roy Sudipto guestEditor.
• Is Part Of: Journal of cellular physiology. Volume 237:Issue 6(2022)
• Page Start: 2644
• Page End: 2653
• Publication Date: 2022-02-06
• Subjects: dynein arm assembly -- dynein arms -- motile cilia; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30689
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: The microtubular scaffold of motile cilia—the axoneme, is decorated with dynein arms, which are large multiprotein complexes essential for ciliary motility. Dynein arms are arranged along the length of the axoneme in a precise repeating pattern, converting chemical energy from ATP hydrolysis into ciliary mechanical movement. How these complicated molecular machines are assembled coordinately and accurately, starting from mere polypeptide chains in the cytoplasm, remains a fascinating yet perplexing question. Rapidly emerging evidence, from multiple studies carried out with different model organisms and with various methodologies, has highlighted the existence of a dedicated assembly pathway. Here, we summarize recent progress made in clarifying the axonemal dynein arm assembly process, focusing on individual assembly steps, including cytoplasmic preassembly, intraflagellar transport, and axonemal docking. Abstract : This article summarized recent progress made in clarifying the axonemal dynein arm assembly process, focusing on individual assembly steps, including cytoplasmic preassembly, intraflagellar transport, and axonemal docking.