Development of polycaprolactone/hydroxyapatite composite resin for 405 nm digital light projection 3D printing. Issue 5 (28th January 2020)

• Record Type: Journal Article
• Authors: Lin, Yuan-Min; Chen, Hsuan; Lin, Chih-Hsin; Huang, Pin-Ju; Lee, Shyh-Yuan
• Is Part Of: Rapid prototyping journal. Volume 26:Issue 5(2020)
• Page Start: 951
• Page End: 958
• Publication Date: 2020-01-28
• Subjects: 3D printing -- Hydroxyapatite -- Polycaprolactone -- Tissue engineering -- Cytotoxicity; Engineering design -- Periodicals; 620.004205
• DOI: 10.1108/RPJ-06-2019-0166
• Languages: English
• ISSNs: 1355-2546

Abstract

Abstract : Purpose: The purpose of this study is to develop resin composite materials composed of polycaprolactone (PCL) acrylates and hydroxyapatite (HA) nanoparticles for ultraviolet digital light projection (DLP) three-dimensional (3D) printing technique. Design/methodology/approach: Two PCL-based triacrylates, namely, glycerol-3 caprolactone-triacrylate (Gly-3CL-TA) and glycerol-6 caprolactone-triacrylate (Gly-6CL-TA) were synthesized from ring-opening polymerization of ε -caprolacton monomer in the presence of glycerol and then acrylation was performed using acryloyl chloride. 3D printing resins made of Gly-3CL-TA or Gly-6CL-TA, 5% HA and 3% of photoinitiator 2, 4, 6-Trimethylbenzoyl-diphenyl-phosphineoxide were then formulated. The surface topography, surface element composition, flexural strength, flexural modulus, cytotoxicity and degradation of the PCL-based scaffolds were then characterized. Findings: Resin composite composed of Gly-3CL-TA or Gly-6CL-TA and 5% (w/w) of HA can be printed by 405 nm DLP 3D printers. The former has lower viscosity and thus can form a more uniform layer-by-layer structure, while the latter exhibited a higher flexural strength and modulus after being printed. Both composite materials are non-cytotoxic and degradable. Originality/value: This study provides a direction of the formulation of environment-friendly resin composite for DLP 3D printing. Both resin composites have huge potential in tissue engineering applications.