Synthesis of biotinylated keratan sulfate repeating disaccharides. Issue 1 (2nd January 2014)

• Record Type: Journal Article
• Authors: Takeda, Naoko; Tamura, Jun-ichi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 1(2014)
• Page Start: 29
• Page End: 37
• Publication Date: 2014-01-02
• Subjects: keratan sulfate -- glycosaminoglycan -- glycosylation -- biotin; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.877834
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: We synthesized four types of keratan and keratan sulfate repeating disaccharides containing non-sulfate, Galβ1-4GlcNAcβ, and three types of sulfates, Gal6Sβ1-4GlcNAcβ, Galβ1-4GlcNAc6Sβ, and Gal6Sβ1-4GlcNAc6Sβ in an efficient and stereo-controlled manner. These disaccharides were conjugated with biotin via a hydrophilic linker at the reducing terminal. Graphical abstract: : Four types of biotinylated keratan sulfate repeating disaccharides containing non-sulfate were synthesized in an efficient and stereo-controlled manner.