Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018). Issue 3 (25th March 2018)

• Record Type: Journal Article
• Authors: Wu, Suhong; Zhang, Aijun; Li, Shumin; Chatterjee, Somik; Qi, Ruogu; Segura‐Ibarra, Victor; Ferrari, Mauro; Gupte, Anisha; Blanco, Elvin; Hamilton, Dale J.
• Is Part Of: Advanced science. Volume 5:Issue 3(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-25
• Subjects: bioenergetic switches -- cancer -- cardiac failure -- mitochondrial transplantation -- surface modification/decoration; Science -- Periodicals; 505
• DOI: 10.1002/advs.201870017
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co‐workers demonstrate that coating mitochondria with a dextran‐triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, and an enhanced shift in the metabolic phenotype of cells compared to uncoated mitochondria.