Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment. (February 2021)

• Record Type: Journal Article
• Authors: Bellavia, Daniele; Dimarco, Eufrosina; Costa, Viviana; Carina, Valeria; De Luca, Angela; Raimondi, Lavinia; Fini, Milena; Gentile, Carla; Caradonna, Fabio; Giavaresi, Gianluca
• Is Part Of: Trends in endocrinology and metabolism. Volume 32:Number 2(2021)
• Page Start: 76
• Page End: 94
• Publication Date: 2021-02
• Subjects: flavonoids -- osteoporosis -- osteoblast -- osteoclast -- bone erosive diseases; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2020.11.007
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytochemicals with therapeutic and preventive effects against bone resorption have recently received increasing attention since they are potentially more suitable for long-term use than traditional therapeutic chemical compounds. In this systematic review of the literature of the past 5 years, comprehensive information is provided on flavonoids with potential antiresorption and pro-osteogenic effects. It aims to highlight the molecular mechanisms of these molecules, often epigenetic, and their possible pharmacological use, which is of great importance for the prevention and treatment of osteoporosis (OP). Highlights: Flavonoids act to promote bone deposition and inhibit bone resorption. Flavonoids, through reduction of oxidative stress, favor bone deposition and inhibit bone resorption, regulating bone homeostasis. Flavonoids act through several mechanisms, such as epigenetic regulation (acetylation/deacetylation, miRNA expression). Flavonoids are demonstrated to act on osteoblast differentiation and activity.