DMAEM‐based cationic polymers as novel carriers for DNA delivery into cells. (6th October 2014)

• Record Type: Journal Article
• Authors: Tanasienko, Iryna V.; Yemets, Alla I.; Finiuk, Nataliya S.; Stoika, Rostyslav R.; Blume, Yaroslav B.
• Is Part Of: Cell biology international. Volume 39:Number 3(2015)
• Page Start: 243
• Page End: 245
• Publication Date: 2014-10-06
• Subjects: cationic polymers (CPs) -- non‐viral gene delivery system -- cell transfection -- poly(dimethylamino‐ethylmethacrylate) (pDMAEM); Cytology -- Periodicals; Cells -- Periodicals; 571.605
• DOI: 10.1002/cbin.10381
• Languages: English
• ISSNs: 1065-6995

Abstract

Abstract: Different transformation systems and vectors have been improved to increase the effectiveness of transformation and achieve stable expression of target genes. Because classical direct and indirect transformation processes commonly suffer from instability of a gene in the environment, gene deletion, transgene silencing, and poor gene transfer efficiency. Nowadays, gene transformation technologies are based on the use of new carriers (nanoparticles, carbon nanotubes, whiskers, and polymers) characterized by better efficiency and reproducibility for the direct DNA delivery into cells. In this review, we have focused on the novel DMAEM‐based direct DNA delivery system and its possible applications for cell transformation.