Sperm morphology: What implications on the assisted reproductive outcomes?. (28th August 2020)
- Record Type:
- Journal Article
- Title:
- Sperm morphology: What implications on the assisted reproductive outcomes?. (28th August 2020)
- Main Title:
- Sperm morphology: What implications on the assisted reproductive outcomes?
- Authors:
- Cito, Gianmartin
Picone, Rita
Fucci, Rossella
Giachini, Claudia
Micelli, Elisabetta
Cocci, Andrea
Falcone, Patrizia
Minervini, Andrea
Carini, Marco
Natali, Alessandro
Coccia, Maria E. - Other Names:
- Corona Giovanni guestEditor.
- Abstract:
- Abstract: Objective: To evaluate the impact of sperm morphology (SM) on laboratory and pregnancy outcomes in conventional intracytoplasmic sperm injection (c‐ICSI) cycles, using the egg donation model to minimize female confounding variables. Materials and methods: We retrospectively collected data of oocyte donation cycles from October 2016 to February 2020. Median seminal parameters, total (1‐2‐3PN) fertilization rate (FR), 2PN FR, cleavage rate (CR), implantation rate (IR), pregnancy rate (PR), miscarriage rate (MR), and live birth rate (LBR) were collected. The study population was divided into three groups: Group 1 with SM < 4%, Group 2 with SM between 4% and 6%, and Group 3 with SM > 6%. Results: Of 741 fresh ICSI cycles and 4507 warmed oocytes were included. Male age was 46.0 (31.0‐72.0) years, and recipients' age was 44.0 (29.0‐54.0) years. Normal SM was 5.0% (1.0%‐15.0%). Male age was negatively correlated with normal SM ( P = .002; Rho −0.113). Oocyte survival rate was 83.3% (16.7%‐100.0%). Total FR was 75.0% (11.1%‐100.0%), 2PN FR was 66.7% (11.1%‐100.0%) %, and CR was 100% (0.0%‐100%). Comparing samples with SM > 6% and those with SM < 4%, 2PN FR was significantly higher in the first group ( P = .04). No significant associations were found among groups in terms of CR. IR was 27.7%, resulting significantly higher when normal SM was > 6% ( P < .01). Clinical PR was 36.0%, MR was 23.9%, and LBR was 25.9%. PR and LBR were significantly higher in samples withAbstract: Objective: To evaluate the impact of sperm morphology (SM) on laboratory and pregnancy outcomes in conventional intracytoplasmic sperm injection (c‐ICSI) cycles, using the egg donation model to minimize female confounding variables. Materials and methods: We retrospectively collected data of oocyte donation cycles from October 2016 to February 2020. Median seminal parameters, total (1‐2‐3PN) fertilization rate (FR), 2PN FR, cleavage rate (CR), implantation rate (IR), pregnancy rate (PR), miscarriage rate (MR), and live birth rate (LBR) were collected. The study population was divided into three groups: Group 1 with SM < 4%, Group 2 with SM between 4% and 6%, and Group 3 with SM > 6%. Results: Of 741 fresh ICSI cycles and 4507 warmed oocytes were included. Male age was 46.0 (31.0‐72.0) years, and recipients' age was 44.0 (29.0‐54.0) years. Normal SM was 5.0% (1.0%‐15.0%). Male age was negatively correlated with normal SM ( P = .002; Rho −0.113). Oocyte survival rate was 83.3% (16.7%‐100.0%). Total FR was 75.0% (11.1%‐100.0%), 2PN FR was 66.7% (11.1%‐100.0%) %, and CR was 100% (0.0%‐100%). Comparing samples with SM > 6% and those with SM < 4%, 2PN FR was significantly higher in the first group ( P = .04). No significant associations were found among groups in terms of CR. IR was 27.7%, resulting significantly higher when normal SM was > 6% ( P < .01). Clinical PR was 36.0%, MR was 23.9%, and LBR was 25.9%. PR and LBR were significantly higher in samples with normal SM > 6%, compared to other groups ( P = .02 and P < .01, respectively). Conclusions: Although c‐ICSI technique allows the embryologist to select the best quality spermatozoa, male factor plays a key role in achieving successful assisted reproductive outcomes. Normal SM has been shown to have implications not only for laboratory outcomes, in terms of fertilization, but also for clinical findings, as regards implantation, pregnancy, and live birth. … (more)
- Is Part Of:
- Andrology. Volume 8:Number 6(2020)
- Journal:
- Andrology
- Issue:
- Volume 8:Number 6(2020)
- Issue Display:
- Volume 8, Issue 6 (2020)
- Year:
- 2020
- Volume:
- 8
- Issue:
- 6
- Issue Sort Value:
- 2020-0008-0006-0000
- Page Start:
- 1867
- Page End:
- 1874
- Publication Date:
- 2020-08-28
- Subjects:
- assisted reproduction -- morphology -- oocyte donation -- semen analysis -- spermatozoa
Andrology -- Periodicals
616.65 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2047-2927 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/andr.12883 ↗
- Languages:
- English
- ISSNs:
- 2047-2919
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0900.445150
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 22184.xml