Reactive lymph node conditions in childhood. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Shaw, Emily C.; Foria, Vipul; Vadgama, Bhumita
• Is Part Of: Diagnostic histopathology. Volume 22:Issue 1(2016)
• Page Start: 17
• Page End: 25
• Publication Date: 2016-01
• Subjects: follicular hyperplasia -- lymph node -- paracortical expansion -- reactive -- sinus histiocytosis; Histology, Pathological -- Periodicals; Cytodiagnosis -- Periodicals; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; Histopathologie -- Périodiques; Pathologie -- Périodiques; Cytodiagnostics -- Périodiques; Diagnostics biologiques -- Périodiques; Histologie -- Technique -- Périodiques; Electronic journals; 616.07582
• DOI: 10.1016/j.mpdhp.2015.12.005
• Languages: English
• ISSNs: 1756-2317

Abstract

Abstract: Lymph node enlargement is a common manifestation of many childhood illnesses. Chronic lymphadenopathy lasting greater than 6 weeks or persistent enlargement of a single lymph node, regional lymph node group or systemic lymphadenopathy in the absence of an obvious cause are indications for lymph node biopsy or excision. In this review we cover common and less common causes of lymph node enlargement in childhood with their characteristic histological features. The most common morphological patterns, including follicular hyperplasia, interfollicular/paracortical expansion, sinus histiocytosis and granulomatous and necrotising lymphadenitis are discussed, with a description of features suggesting specific underlying aetiology and other adjuncts to precise diagnosis.