Subtype distribution of zoonotic pathogen Cryptosporidium felis in humans and animals in several countries. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Jiang, Wen; Roellig, Dawn M.; Lebbad, Marianne; Beser, Jessica; Troell, Karin; Guo, Yaqiong; Li, Na; Xiao, Lihua; Feng, Yaoyu
• Is Part Of: Emerging microbes & infections. Volume 9:Issue 1(2020)
• Page Start: 2446
• Page End: 2454
• Publication Date: 2020-01-01
• Subjects: Cryptosporidium felis -- subtypes -- subtype families -- host adaption -- geographic distribution; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2020.1840312
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: Cryptosporidium felis is the major etiologic agent of cryptosporidiosis in felines and has been reported in numerous human cryptosporidiosis cases. Sequence analysis of the 60-kDa glycoprotein ( gp60 ) gene has been developed for subtyping C. felis recently. In this study, 66 C. felis isolates from the United States, Jamaica, Peru, Portugal, Slovakia, Nigeria, Ethiopia, Kenya, China, India and Australia were subtyped using the newly established tool. Forty-four specimens yielded gp60 sequences, generating 23 subtypes clustered in 4 subtype families (XIXa, XIXc, XIXd and XIXe) with high bootstrap support in a phylogenetic analysis of sequence data. Among them, XIXa showed high genetic diversity at the nucleotide level, with the formation of 18 subtypes from both cats and humans with different geographic distribution. In contrast, all 11 XIXd isolates derived from humans from various countries had identical sequences. Results of this study improve our understanding of the genetic diversity, host specificity and transmission dynamics of C. felis .