Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Favara, D. M.; Ceron-Gutierrez, M. L.; Carnell, G. W.; Heeney, J. L.; Corrie, P.; Doffinger, R.
• Is Part Of: Emerging microbes & infections. Volume 9:Issue 1(2020)
• Page Start: 2728
• Page End: 2731
• Publication Date: 2020-01-01
• Subjects: SARS-CoV-2 -- COVID-19 -- antibody -- IgG -- IgA -- breastmilk; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2020.1858699
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed.