Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Bao, Juan; Wu, Nannan; Zeng, Yigang; Chen, Liguang; Li, Linlin; Yang, Lan; Zhang, Yiyuan; Guo, Mingquan; Li, Lisha; Li, Jie; Tan, Demeng; Cheng, Mengjun; Gu, Jingmin; Qin, Jinghong; Liu, Jiazheng; Li, Shiru; Pan, Guangqiang; Jin, Xin; Yao, Bangxin; Guo, Xiaokui; Zhu, Tongyu; Le, Shuai
• Is Part Of: Emerging microbes & infections. Volume 9:Issue 1(2020)
• Page Start: 771
• Page End: 774
• Publication Date: 2020-01-01
• Subjects: Bacteriophage -- phage therapy -- antibiotic resistance -- urinary tract infection; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2020.1747950
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail inhibited the emergence of phage resistant mutant in vitro, and the UTI of patient was successfully cured by this combination. Thus, we propose that non-active antibiotic and bacteriophage synergism (NABS) might be an alternative strategy in personalized phage therapy.