Phospholipid fraction has protective effect by improving inflammation and skin barrier function in ischemia-reperfusion injury in mice. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Kim, Su-Young; Kim, Yu-jin; Lee, Esther; Choi, Seong Hyun; Moon, Jeong Su; An, Hyo Sil; Ji, Eun Su; Na, Jungtae; Kim, Beom Joon
• Is Part Of: All life. Volume 13:Issue 1(2020)
• Page Start: 623
• Page End: 633
• Publication Date: 2020-01-01
• Subjects: Phospholipid -- pressure ulcer -- inflammation -- macrophages -- collagen -- microvessel; Life sciences -- Periodicals; Biology -- Periodicals; Electronic journals; Periodicals; 570.5
• DOI: 10.1080/26895293.2020.1838334
• Languages: English
• ISSNs: 2689-5293

Abstract

ABSTRACT: The total phospholipid fraction (TPF) has anti-inflammatory properties and reduces apoptosis in animal models. Our objective was to assess the effects of TPF on pressure ulcers in a mouse model of cutaneous ischemic-reperfusion (I/R) injury. Cutaneous I/R injury was created by trapping the dorsal skin between two magnetic disks for 12 h, followed by disk removal. TPF administration in I/R areas at the beginning of reperfusion significantly inhibited the formation of pressure ulcers. The number of neutrophils and M1 macrophages and the levels of proinflammatory mediators MCP-1, IL-1β, IL-6, and TNF-α in the wound area were reduced upon TPF treatment. Collagen synthesis and α-SMA-positive microvessel density significantly increased in the wounds of TPF-treated mice. Additionally, TPF inhibited cutaneous I/R injury-induced formation and accumulation of apoptotic cells. Moreover, TPF increased the expression of filaggrin and involucrin. In conclusion, TPF may inhibit cutaneous I/R injury-induced formation of pressure ulcers by regulating inflammation, collagen production, angiogenesis, and skin barrier restoration. Therefore, exogenous application of TPF might have therapeutic potential with respect to cutaneous I/R injuries like decubitus ulcers.