Exploration of endoscopic findings and risk factors of early gastric cancer after eradication of Helicobacter pylori. (4th March 2021)

• Record Type: Journal Article
• Authors: Yan, Xiaohan; Hu, Xiao; Duan, Bensong; Zhang, Xuesong; Pan, Jie; Fu, Jindong; Xu, Meidong; Xu, Qinwei
• Is Part Of: Scandinavian journal of gastroenterology. Volume 56:Number 3(2021)
• Page Start: 356
• Page End: 362
• Publication Date: 2021-03-04
• Subjects: Early gastric cancer -- eradication of Helicobacter pylori -- endoscopic -- intermediate zone; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2020.1868567
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Aim: To explore the endoscopic features and risk factors of early gastric cancer (EGC) after eradication of Helicobacter pylori ( H. pylori ). Methods: A total of 1961 patients who underwent esophago-gastro-duodenoscopy (EGD) with a history of successful H. pylori eradication were enrolled in this multicenter research. Among them, 162 EGC lesions of 132 patients were detected. The endoscopic features and risk factors of post-eradication EGC were explored. Results: Severe atrophy (75.3% vs. 16.7%, p value <.01), intestinal metaplasia (96.3% vs. 77.1%, p value <.01), map-like redness (89.5% vs. 65.4%, p value <.01), distinct intermediate zone (IZ) (68.5% vs. 23.4%, p value <.01) and xanthoma (58.0% vs. 17.9%, p value <.01) were significantly more frequent in the CA group (patients with newly detected EGC after eradication of H. pylori ) than in the NC group (patients without gastric cancer after eradication of H. pylori ). In multivariate analysis, severe atrophy (odds ratio (OR) = 8.08; 95% confidence interval (CI), 3.43–20.0; p value<.01), map-like redness (OR = 1.75; 95% CI, 0.11–5.25; p value = .04), distinct IZ (OR = 2.87; 95% CI, 1.20–6.93; p value = .02) and xanthoma (OR = 2.84; 95% CI, 1.20–7.03; p value=.02) were proved to be risk factors for detection of EGC after eradication of H. pylori . Conclusions: Severe atrophy and map-like redness and distinct IZ and xanthoma are risk factors of EGC after eradication of H. pylori .