Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Wang, Lin; Yan, Li; Jiang, Jieling; Zhang, Yuyi; He, Qiyu; Zhuang, Hui; Wang, Ling
• Is Part Of: Emerging microbes & infections. Volume 9:Issue 1(2020)
• Page Start: 994
• Page End: 997
• Publication Date: 2020-01-01
• Subjects: Hepatitis E virus -- hepatitis E -- extra-hepatic replication -- bone marrow; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2020.1761762
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence.