Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Elbediwi, Mohammed; Pan, Hang; Biswas, Silpak; Li, Yan; Yue, Min
• Is Part Of: Emerging microbes & infections. Volume 9:Issue 1(2020)
• Page Start: 535
• Page End: 538
• Publication Date: 2020-01-01
• Subjects: Salmonella Newport -- antimicrobial resistance -- colistin resistance -- mcr-1 -- seafood; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2020.1733439
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: Worldwide emergence of Salmonella enterica serovar Newport ( S . Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S . Newport resistance in China remains largely unknown. A retrospective study of 287 S. Newport clinical isolates collected during 1997–2018 was undertaken for characterization of AR profiles using the micro-dilution assay. We found a recent emergence of colistin resistance in four Chinese clinical isolates, including mcr -1-positive isolates. Importantly, phylogenomic and microbiological investigations indicate multiple independent clonal transmission of colistin-resistant S. Newport isolates of different seafood origins. Our study highlights potential reservoirs for transmission of colistin resistance and suggests that the global food supply chain may facilitate this dissemination.