A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions. Issue 9 (1st September 2020)

• Record Type: Journal Article
• Authors: Kim, Dae-Kyum; Knapp, Jennifer J; Kuang, Da; Chawla, Aditya; Cassonnet, Patricia; Lee, Hunsang; Sheykhkarimli, Dayag; Samavarchi-Tehrani, Payman; Abdouni, Hala; Rayhan, Ashyad; Li, Roujia; Pogoutse, Oxana; Coyaud, Étienne; van der Werf, Sylvie; Demeret, Caroline; Gingras, Anne-Claude; Taipale, Mikko; Raught, Brian; Jacob, Yves; Roth, Frederick P
• Is Part Of: G3. Volume 10:Issue 9(2020)
• Page Start: 3399
• Page End: 3402
• Publication Date: 2020-09-01
• Subjects: SARS-CoV-2 -- coding sequence collection -- Gateway-compatible -- TEV (tobacco etch virus) sequence; Genetics -- Research -- Periodicals; Genomics -- Periodicals; Genetics; Genomics; Genes; Genetics -- Research; Genomics; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 572.8
• DOI: 10.1534/g3.120.401554
• Languages: English
• ISSNs: 2160-1836

Abstract

Abstract: The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.