Efficient metal-free green syntheses of 4H-chromenes and 3-amino alkylated indoles using a reusable graphite oxide carbocatalyst under aqueous and solvent-free reaction conditions. (1st June 2022)

• Record Type: Journal Article
• Authors: Kyndiah, Lenida; Sarkar, Fillip Kumar; Gupta, Ajay; Pal, Amarta Kumar
• Is Part Of: New journal of chemistry. Volume 46:Number 24(2022)
• Page Start: 11706
• Page End: 11721
• Publication Date: 2022-06-01
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d2nj00756h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Graphite oxide was employed as a reusable catalyst for the synthesis of 4 H -chromenes and 3-amino alkylated indoles in aqueous and solvent-free reaction conditions. Abstract : Graphite oxide (GO) was utilized for the one-pot three-component syntheses of pharmaceutically important 4 H -chromenes and 3-amino alkylated indoles in water and solvent-free reaction conditions, respectively. Spectroscopic techniques such as FT-IR, XPS, SEM, TEM, SAED, EDX, PXRD, Raman, and TGA confirmed the formation and thermal stability of GO. These protocols provide green and sustainable reaction conditions, including excellent catalytic activity, good to excellent yield of the products, reusability of the catalyst, high functional group tolerance, and Gram-scale synthesis. Further, the present methodologies exclude the problems of metal toxicity, metal waste disposal, metal contamination in the products, and the use of volatile organic solvents.