Endometrial Receptivity Testing and Adjustment to Window of Implantation Timing Improve Pregnancy Rates with Assisted Reproductive Technology (ART) [A334]. (May 2022)

• Record Type: Journal Article
• Authors: Rose-Reneau, Zak; Riggs, Ryan N.; Anderson, Derica K.
• Is Part Of: Obstetrics and gynecology. Volume 139(2022)Supplement 1
• Page Start: 96S
• Page End: 96S
• Publication Date: 2022-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1097/01.AOG.0000825452.97976.94
• Languages: English
• ISSNs: 0029-7844

Abstract

Abstract : INTRODUCTION: For decades, reproductive endocrinology and infertility (REI) research focused on solely on the creation of a viable embryo to increase pregnancy rates. Recently, research has identified the impact of endometrial adhesion molecule expression during the window of implantation (WOI) as playing a major role in embryo implantation. METHODS: This is a retrospective case-control study of women undergoing assisted reproductive technology and the effects of the IgenomixEndometrial Receptivity Assay (ERA) on pregnancy success rates following frozen embryo transfer. RESULTS: ERA results showed 29 of 60 patients were normal, 20 of 60 patients were Early Receptive (WOI existing 12 hours later than expected), and 11 of 60 patients were Pre-Receptive (WOI existing 24 hours later than expected). Ninety-one percent of patients with a corrected abnormal ERA had successful pregnancies, whereas only 72% achieved successful pregnancy without using ERA to assess for their WOI ( P ≤.01; odds ratio, 3.82). CONCLUSION: Endometrial Receptivity Assay testing has a significant impact on successful pregnancy rates among patients undergoing ART. Women should be encouraged to undergo ERA testing to ensure accurate timing of their WOI for embryo transfer. Although numerous medication changes can be made by the physician to improve implantation success rates, if the WOI timing is not accounted for, those changes are for naught because the endometrium is not prepared to receive the embryo and subsequent embryo implantation into the endometrium will not occur. The use of ERA could save the patient tens of thousands of dollars and shave years off their time to achieving successful pregnancies.