Poor Glycemic Control Is a Risk Factor for Triple-Negative Breast Cancer in Patients With Type 2 Diabetes [A323]. (May 2022)

• Record Type: Journal Article
• Authors: Miller, Madison; Bell, Myah; Holland, Priscella; Ibrahim, Vanessa; Jacobsen, Gordon; Swain, Monique
• Is Part Of: Obstetrics and gynecology. Volume 139(2022)Supplement 1
• Page Start: 93S
• Page End: 93S
• Publication Date: 2022-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1097/01.AOG.0000825612.87300.43
• Languages: English
• ISSNs: 0029-7844

Abstract

Abstract : INTRODUCTION: We sought to investigate the relationship between glycemic control, race, and the incidence of triple-negative breast cancer (TNBC) among patients with type 2 diabetes (T2D). METHODS: A retrospective cohort study evaluating 1, 416 patients with T2D diagnosed with breast cancer between 2015 and 2020 was conducted. Tumor subtype was categorized as either hormone receptor-positive (ER+, PR+, or both) or triple-negative (ER/PR- and HER2/neu-). Based on Hgb A1c measured within 3 months of cancer diagnosis, patients were assigned to one of three categories: well-controlled (Hgb A1c less than 7.0), moderately controlled (Hgb A1c 7.0-9.4), or poorly controlled (Hgb A1c greater than or equal to 9.5) T2D. RESULTS: A significant increase in the percentage of non-Hispanic White patients with TNBC across the three levels of glycemic control was observed ( P =.037). When racial comparisons of cancer subtype within categories of glycemic control were performed, a significant ( P= .001) increase in the percentage of Black patients with TNBC compared with non-Hispanic White patients was only observed among those with well-controlled T2D. CONCLUSION: Although previous studies have shown that Black patients are 2 to 3 times more likely to develop TNBC than their non-Hispanic White counterparts, a statistically significant racial difference was only noted among our patients with well-controlled T2D. Thus, our data not only suggest that T2D may serve as a modifiable risk factor for the development of TNBC but also that the risk conferred by poor glycemic control may bear more significance for non-Hispanic White patients than Black patients.