Racial Disparity in Neonatal Outcomes in Pregnancies Conceived Via In Vitro Fertilization [A277]. (May 2022)

• Record Type: Journal Article
• Authors: Bar-El, Liron; Yeshua, Arielle; Eliner, Yael; Chervenak, Frank; Bornstein, Eran
• Is Part Of: Obstetrics and gynecology. Volume 139(2022)Supplement 1
• Page Start: 80S
• Page End: 80S
• Publication Date: 2022-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1097/01.AOG.0000825668.26181.a5
• Languages: English
• ISSNs: 0029-7844

Abstract

Abstract : INTRODUCTION: Increased adverse maternal and neonatal outcomes are seen in Black compared to White U.S. women. Pregnancies conceived via in vitro fertilization (IVF) represent a unique population, often with appropriate pre-pregnancy medical care, access to prenatal care, and overall higher socioeconomic status. Thus, we set out to assess whether similar racial disparities exist in pregnancies following IVF. METHODS: We performed a retrospective analysis of the CDC's natality database (2016–2018) of births conceived via IVF in women who self-identified as non-Hispanic Black and non-Hispanic White. Pearson's Chi-square test was used to compare several pregnancy and neonatal outcomes among women of both races. Multivariate logistic regression adjusted the outcomes for potential confounders. Results are presented as adjusted odds ratios (aORs) with a 95% confidence interval (CI). Statistical significance was set as P -value less than .05. RESULTS: Non-Hispanic Black women had a lower risk for gestational diabetes (aOR 0.8, CI 0.7–0.9), hypertensive disorders of pregnancy (aOR 0.8, CI 0.7–0.9), eclampsia (aOR 0.9, CI 0.9–1), and neonatal immediate and prolonged ventilation (aOR 0.7, CI 0.7–0.8; aOR 0.75, CI 0.6–0.8; respectively) than non-Hispanic White women. No difference was found in the rate of preterm deliveries, maternal intensive care unit admissions, gravid hysterectomies, neonatal intensive care unit admissions, and newborn antibiotics ( P >.05). CONCLUSION: Based on this extensive U.S. database, maternal and neonatal complications that are generally seen more frequently in Black women are, in fact, lower in Black compared to White women in the IVF population. These findings may indicate that different socioeconomic factors, rather than race per se, are at play. Further research is needed to explore the causes of this disparity.