Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery. Issue 2 (9th October 2019)

• Record Type: Journal Article
• Other Names: Chapman SJ investigator.; Clerc D investigator.; Blanco‐Colino R investigator.; Otto A investigator.; Nepogodiev D investigator.; Pagano G investigator.; Schaeff V investigator.; Soares A investigator.; Zaffaroni G investigator.; Žebrák R investigator.; Hodson J investigator.; Blanco‐Colino R investigator.; Chapman SJ investigator.; Glasbey JC investigator.; Pata F investigator.; Pellino G investigator.; Sgrò A investigator.; Soares A investigator.; van Elst T investigator.; Van Straten S investigator.; Knowles CH investigator.; Nepogodiev D investigator.; Hodson J investigator.; Borakati A investigator.; Bath MF investigator.; Yasin IH investigator.; Mclean K investigator.; Arthur T investigator.; Kovacevic M investigator.; Delibegovic S investigator.; Karamanliev M investigator.; Swamad M investigator.; Žebrák R investigator.; Paramasivam R investigator.; Martensen A investigator.; Larsen HM investigator.; Rädeker L investigator.; Frey PE investigator.; Kechagias A investigator.; Venara A investigator.; Duchalais E investigator.; Ioannidis A investigator.; Pata F investigator.; Pellino G investigator.; Pasquali S investigator.; Sgrò A investigator.; Simioni A investigator.; Farina V investigator.; Podda M investigator.; Lorenzon L investigator.; investigator.; Schaeff V investigator.; Otto A investigator.; Jakubauskas M investigator.; van Elst TR investigator.; Chu M investigator.; Fagan PVB investigator.; Wells CI investigator.; Alagoa João A investigator.; Soares A investigator.; Juloski J investigator.; Clerc D investigator.; Ciubotaru C investigator.; Popescu S investigator.; Yanishev A investigator.; Lee S investigator.; Ozkan BB investigator.; Yagız Sen A investigator.; Aktas MK investigator.; Baki BE investigator.; Yüksek B investigator.; Glasbey JC investigator.; Kamarajah S investigator.; Mclean K investigator.; Borakati A investigator.; Yasin IH investigator.; Khaw RA investigator.; Mills E investigator.; Goodson R investigator.; Thakral N investigator.; investigator.; Ablett AD investigator.; Adra M investigator.; Kwek I investigator.; Khan SM investigator.; Quinn P investigator.; Manley LR investigator.; Badran A investigator.; Ramjeeawon A investigator.; Campbell A investigator.; Tan HL investigator.; Rye DS investigator.; Rajaraman N investigator.; Norman JG investigator.; Vutipongsatorn K investigator.; Solomou G investigator.; Akhbari M investigator.; Ali A investigator.; Murray V investigator.; Baker DM investigator.; Brandao BD investigator.; Stainer B investigator.; Thavayogan R investigator.; Jones D investigator.; Onafowokan OO investigator.; Gharooni A investigator.; Dabab N investigator.; Carlton‐Carew S investigator.; Kungwengwe G investigator.; Gabriel M investigator.; Sewart E investigator.; Shortland TC investigator.; Lawday S investigator.; Pockney P investigator.; Dawson A investigator.; Arthur T investigator.; Brumfitt CD investigator.; Stewart P investigator.; Ng B investigator.; Luong JK investigator.; Delibegovic S investigator.; Ivanov V investigator.; Borisova A investigator.; Neykov V investigator.; Kunčarová K investigator.; Kološová B investigator.; Antonova T investigator.; Farkašová M investigator.; Žebrák R investigator.; Harbjerg JL investigator.; Brandsborg S investigator.; Brinck S investigator.; Kjaer MD investigator.; Mark‐Christensen A investigator.; Unbehaun KP investigator.; Dalsgaard P investigator.; Lycke KD investigator.; Kechagias A investigator.; LeNaoures P investigator.; Duchalais E investigator.; Brigand C investigator.; Dumange E investigator.; Gout M investigator.; Moehwald C investigator.; Prem M investigator.; Alhalabi O investigator.; Sliwinski S investigator.; Krupp J investigator.; Gablenz E investigator.; Schmitzer L investigator.; Kopp A investigator.; Steinle J investigator.; Gsenger J investigator.; Pohl LJ investigator.; Riccardi M investigator.; Christodoulou IM investigator.; Konstantinidis M investigator.; Machairas N investigator.; Zoikas A investigator.; Balalis D investigator.; Manatakis DK investigator.; Aguilera ML investigator.; Sgrò A investigator.; Simioni A investigator.; Marano L investigator.; Fleres F investigator.; Lovisetto F investigator.; Sasia D investigator.; Segalini E investigator.; Pata G investigator.; Lucchi A investigator.; Sagnotta A investigator.; Campagnaro T investigator.; Petrelli F investigator.; Gallo G investigator.; Papandrea M investigator.; Testa V investigator.; Sinibaldi G investigator.; Di Candido F investigator.; Colombo F investigator.; Perrone G investigator.; Aresu S investigator.; Biancafarina A investigator.; Canonico G investigator.; Pagnanelli M investigator.; Curletti G investigator.; Bini R investigator.; de Manzoni Garberini A investigator.; Impellizzeri H investigator.; Cillara N investigator.; Tutino R investigator.; Picciariello A investigator.; Coletta D investigator.; Savino G investigator.; Ferrara F investigator.; Tamini N investigator.; Talamo G investigator.; Parini D investigator.; Giamundo P investigator.; lo Conte A investigator.; Pagano G investigator.; Ripetti V investigator.; Pesce A investigator.; Menduni N investigator.; Pellino G investigator.; Giudicissi R investigator.; Podda M investigator.; Goldin E investigator.; Rega D investigator.; Belli A investigator.; Andriola V investigator.; Gordini L investigator.; Pata F investigator.; Foppa C investigator.; Piccolo G investigator.; Birindelli A investigator.; Ferrari C investigator.; Ballarini Z investigator.; Tirelli F investigator.; Milone M investigator.; De Rosa M investigator.; Pipitone Federico NS investigator.; Molteni B investigator.; Tilocca PL investigator.; Sancini G investigator.; Piozzi GN investigator.; Lauretta A investigator.; Poillucci G investigator.; Mulas S investigator.; Schaeff V investigator.; Otto A investigator.; Jakubauskas M investigator.; Simcikas D investigator.; Portelli L investigator.; van Wijnbergen JWM investigator.; Dinger TL investigator.; ten Doesschate SFH investigator.; van Dalen ASHM investigator.; van den Bos DD investigator.; Hansmann M investigator.; Medina Feliz J investigator.; Kuiper SZ investigator.; Abdulrahman Z investigator.; Pruijssers SR investigator.; Farik S investigator.; Elliott BM investigator.; Geneta VP investigator.; Chu M investigator.; Wilton S investigator.; Kandelaki H investigator.; Peng SL investigator.; Campbell S investigator.; Lim YK investigator.; Yassaie SS investigator.; Murray M investigator.; Fagan PVB investigator.; Haran C investigator.; Tan J investigator.; Castro J investigator.; Laranjeira A investigator.; Catarino S investigator.; Neves‐Marques C investigator.; Correia JG investigator.; Vieira BN investigator.; Quintela AC investigator.; Serra ML investigator.; Maciel J investigator.; Cunha M investigator.; Aparício DJ investigator.; Neves J investigator.; Azevedo J investigator.; Romano M investigator.; Eiró F investigator.; Romano J investigator.; Monteiro C investigator.; Claro M investigator.; Almeida MR investigator.; Peyroteo M investigator.; Machado ND investigator.; Capote H investigator.; Ferreira M investigator.; Sousa X investigator.; Devesa H investigator.; Cavadas D investigator.; Guerreiro I investigator.; Costa M investigator.; Salman M investigator.; English C investigator.; Mohammed N investigator.; Popescu S investigator.; Yanishev A investigator.; Litvin A investigator.; Ćuk VV investigator.; Mészárosová K investigator.; Van Straten S investigator.; Jaich R investigator.; De Lima H investigator.; Brooks S investigator.; Marx M investigator.; Nshalati Salvation M investigator.; Clerc D investigator.; Blaser B investigator.; Piazza G investigator.; Gagliardi B investigator.; Serin H investigator.; Yagız Sen A investigator.; Yurdaor SS investigator.; Aktas MK investigator.; Arslan E investigator.; Kopac O investigator.; Uyanik A investigator.; Ozmen BB investigator.; Tiftik E investigator.; Aksoy B investigator.; Yalcinkaya A investigator.; Ozoglu F investigator.; Kocer MD investigator.; Bilicen G investigator.; Cinar EN investigator.; Uslu Ö investigator.; Kaya Y investigator.; Wong J investigator.; Farhan‐Alanie MMH investigator.; Suresh G investigator.; Asif A investigator.; Finch BJ investigator.; Bhahirathan Y investigator.; Herron J investigator.; Yi Tew Z investigator.; Obukofe R investigator.; Russell C investigator.; Suchett‐Kay I investigator.; Netke T investigator.; Williams L investigator.; Kisiel A investigator.; Liu FY investigator.; Claireaux H investigator.; James P investigator.; Mondal A investigator.; Kalderon R investigator.; Nadama HH investigator.; Al‐Saraff Z investigator.; Tam JPH investigator.; Powell‐Chandler A investigator.; Wood F investigator.; Campbell A investigator.; Gorgievska Rebecca investigator.; Ragavoodoo A investigator.; Thakrar C investigator.; Rojoa D investigator.; Palmer C investigator.; Davidson K investigator.; Giacci L investigator.; Hale J investigator.; Gan FW investigator.; Makin‐Taylor R investigator.; Hey CY investigator.; Toh C investigator.; Findlay JM investigator.; Griffiths N investigator.; Ganesananthan S investigator.; Jasionowska S investigator.; Poustie M investigator.; Wong C investigator.; Turner T investigator.; Pyc W investigator.; Sloper W investigator.; Warner C investigator.; Coey J investigator.; Mason D investigator.; Sait S investigator.; Kowal M investigator.; Shortland TC investigator.; Owen M investigator.; Saiyed A investigator.; Ashworth I investigator.; Akbari K investigator.; Curran M investigator.; Martin P investigator.; Parker D investigator.; Dawson A investigator.; Kwok K investigator.; Lye C investigator.; Pockney P investigator.; Ghaly M investigator.; Sammour T investigator.; Lewis D investigator.; Mundasad R investigator.; Wilkes A investigator.; Ctercteko G investigator.; Stewart P investigator.; Delibegovic S investigator.; Maslyankov S investigator.; Dimov R investigator.; Iliev S investigator.; Dimitrov D investigator.; Marek F investigator.; Örhalmi J investigator.; Skalický P investigator.; Skalický T investigator.; Chrz K investigator.; Christensen P investigator.; Worsøe J investigator.; Kristensen ES investigator.; Emmertsen KJ investigator.; Loeve US investigator.; Duchalais E investigator.; Mihaljevic AL investigator.; Herrle F investigator.; Konstantinidis KM investigator.; Manatakis DK investigator.; Korkolis D investigator.; Karanikas I investigator.; Aguilera ML investigator.; Vincenti L investigator.; Anania G investigator.; Borghi F investigator.; Agresta F investigator.; Maretto I investigator.; Parisi A investigator.; Bucci L investigator.; De Palma G investigator.; Guglielmi A investigator.; Cucinotta E investigator.; La Torre F investigator.; Cianchi F investigator.; Guerrieri M investigator.; Lauretta A investigator.; Trompetto M investigator.; Persiani R investigator.; Micheletto G investigator.; Delrio P investigator.; Belli A investigator.; Cantafio S investigator.; Lovisetto F investigator.; Ronconi M investigator.; Bisagni PAG investigator.; De Prizio M investigator.; Tamini N investigator.; Sinibaldi G investigator.; Franceschi A investigator.; Galleano R investigator.; Cavallini M investigator.; Brescia A investigator.; D'Ambra L investigator.; Benevento A investigator.; Niolu P investigator.; Calgaro M investigator.; Colangelo E investigator.; Grottola T investigator.; Altomare DF investigator.; Puleo S investigator.; Salamone G investigator.; Pietrabissa A investigator.; Poggioli G investigator.; Ripetti V investigator.; Erdas E investigator.; Ottonello R investigator.; Canonico G investigator.; Tonini V investigator.; Selvaggi F investigator.; Sammarco G investigator.; Ceccarelli G. investigator.; De Nisco C investigator.; Surgo D investigator.; Taglietti L. investigator.; Ozolins A investigator.; Sivinš A investigator.; Poskus T investigator.; Psaila J investigator.; Bemelman WA investigator.; Graat LJ investigator.; Langenhoff B investigator.; Wijnhoven BPL investigator.; van de Ven AHW investigator.; Poelman M investigator.; Stassen LPS investigator.; Slooter G investigator.; Acherman YIZ investigator.; Hoff C investigator.; Gerhards MF investigator.; Stommel MWJ investigator.; Hazebroek EJ investigator.; van Geloven AAW investigator.; Schasfoort RA investigator.; van Leeuwen BL investigator.; Tuynman JB investigator.; van Tilburg MWA investigator.; Boerma EG investigator.; Sharma P investigator.; Jenkins B investigator.; Bissett IP investigator.; Peng SL investigator.; Herd A investigator.; Gordon A investigator.; Vernon D investigator.; Omundsen M investigator.; Ly J investigator.; Reddy A investigator.; Bonnet G investigator.; Harmston C investigator.; Morales M investigator.; Francisco V investigator.; Costa S investigator.; Manso A investigator.; Amorim E investigator.; Pereira J investigator.; Cardoso J investigator.; Ourô S investigator.; Caratão M investigator.; Nascimento C investigator.; Ribeiro da Silva B investigator.; Taranu V investigator.; Dias R investigator.; Devesa H investigator.; Mendes J investigator.; Allen M investigator.; Silva A investigator.; Carlos S investigator.; Barbosa E investigator.; Carneiro C investigator.; Ramos L investigator.; Maciel J investigator.; Lencastre L investigator.; Martins R investigator.; Silva‐Vaz P investigator.; Ridgway PF investigator.; McNamara DA investigator.; Cahill R investigator.; Hogan A investigator.; Larkin J investigator.; O'Connell PR investigator.; Negoi I investigator.; Abelevich A investigator.; Ćuk VM investigator.; Vician M investigator.; Ede C investigator.; Sardiwalla I investigator.; Mulira S investigator.; Montwedi D investigator.; Oyomno M investigator.; Hübner M investigator.; Petermann D investigator.; Sauvain MO investigator.; Ozben V investigator.; Geçim IE investigator.; Disçi E investigator.; Rencuzogullari A investigator.; Kurt A investigator.; Bisgin T investigator.; Pehlivan M investigator.; Isik A investigator.; Onur E investigator.; Leventoglu S investigator.; Haksal MC investigator.; Erturk MS investigator.; Keskin M investigator.; Guner A investigator.; Tutcu Sahin S investigator.; Ozbalci GS investigator.; Pergel A investigator.; Albayrak D investigator.; Bruce D investigator.; Fearnhead N investigator.; Arthur J investigator.; Harron M investigator.; Beattie G investigator.; Titu L investigator.; Ali A investigator.; Saunders M investigator.; Phillips J investigator.; Dindyal S investigator.; Cresswell B investigator.; Gercek Y investigator.; Lee J investigator.; Linn T investigator.; Faulkner G investigator.; Lockwood S investigator.; Rees J investigator.; Charalabopoulos A investigator.; Campbell B investigator.; Kontovounisios C investigator.; Amarnath T investigator.; Johnson M investigator.; Epanomeritakis E investigator.; Vigs S investigator.; Nastro P investigator.; Gilliam A investigator.; Smolarek S investigator.; Wilson T investigator.; Orbell J investigator.; McIntyre R investigator.; Agarwal T investigator.; Hainsworth P investigator.; Patel P investigator.; Vijay J investigator.; Liu B investigator.; Dhruva Rao P investigator.; Roxburgh C investigator.; Vipond M investigator.; Youssef H investigator.; Thorn C investigator.; Schizas A investigator.; Denley S investigator.; Bowley D investigator.; Das K investigator.; Cuming T investigator.; Saha A investigator.; Chung L investigator.; Pitt J investigator.; Davis P investigator.; Jones O investigator.; Taylor M investigator.; Bhargava A investigator.; Haji A investigator.; Watson N investigator.; Bloom I investigator.; Singh B investigator.; Norwood M investigator.; Gurjar S investigator.; Stylianides N investigator.; Mirza S investigator.; Evans M investigator.; Williams G investigator.; Patil P investigator.; Hernon J investigator.; Finch G investigator.; Green S investigator.; Chapple K investigator.; Fafemi O investigator.; Warusavitarne J investigator.; Samee A investigator.; Carden C investigator.; Ong L investigator.; Verma K investigator.; Joseph A investigator.; Rawat N investigator.; Pinkney T investigator.; Oke O investigator.; Glen P investigator.; Maxwell‐Armstrong C investigator.; Oliphant R investigator.; Garner J investigator.; Moug SJ investigator.; Middleton S investigator.; Lund JN investigator.; Smart NJ investigator.; Osborn G investigator.; Moore T investigator.; Raymond T investigator.; Knowles CH investigator.; Hany TS investigator.; Clarke R investigator.; Khera G investigator.; Brady R investigator.; Sellahewa C investigator.; Mason C investigator.; Torrance A investigator.; Lasithiotakis K investigator.; Knight J investigator.; Pullybank A investigator.; Ainsworth P investigator.; Reid F investigator.; Ramwell A investigator.; Maslekar S investigator.; George R investigator.; Skull A investigator.; Holtham S investigator.; Muhammad K investigator.; Lal R investigator.; Varcada M investigator.; Smith FM investigator.; Howlader M investigator.; Defriend D investigator.; Kirk S investigator.; Richards T investigator.; Evans C investigator.; Borg C investigator.; Telford K investigator.; Sarfraz N investigator.; Busby K investigator.; Hollingshead J investigator.; 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Gaetano P investigator.; Pilotta F investigator.; Baldassarre L investigator.; Perrone G investigator.; Bonati E investigator.; Aresu S investigator.; Saba A investigator.; Moretto G investigator.; Bacchion M investigator.; Impellizzeri H investigator.; Casaril A investigator.; Inama M investigator.; Creciun M investigator.; Ferrara F investigator.; Stella M investigator.; Gobatti D investigator.; Biancafarina A investigator.; Angelini M investigator.; Andolfi E investigator.; Miranda E investigator.; Scricciolo M investigator.; Provenza G investigator.; Cavallina G investigator.; Frezza B investigator.; Fontani A investigator.; Malatesti R investigator.; Pellicanò GA investigator.; Podda M investigator.; Anania M investigator.; Pulighe F investigator.; Cruccu A investigator.; Murru ML investigator.; Massaiu C investigator.; Balestra F investigator.; Pazzona M investigator.; De Nisco C investigator.; Giannella A investigator.; Santangelo M investigator.; Olivieri M investigator.; Frangella F investigator.; Magagnano D investigator.; Liberatore P investigator.; Brenna R investigator.; Giani A investigator.; Tirotta F investigator.; Famularo S investigator.; Angrisani M investigator.; Ceresoli M investigator.; De Rosa M investigator.; Rondelli F investigator.; Ceccarelli G investigator.; Angelucci GP investigator.; Scaramuzzo R investigator.; Larcinese A investigator.; Fioriti C investigator.; Picone E investigator.; Nardi M investigator.; Marano L investigator.; Castagnoli G investigator.; Bartoli A investigator.; Bellochi R investigator.; Spaziani A investigator.; Conti D investigator.; Poponesi V investigator.; Trippetti M investigator.; Amicucci S investigator.; Tazza G investigator.; Procacci P investigator.; Giovannini F investigator.; Basile E investigator.; Franceschi A investigator.; Caristo G investigator.; Pagnanelli M investigator.; De Nardi P investigator.; Rosati R investigator.; Marcocci G investigator.; Vignali A investigator.; Curletti G investigator.; Galleano R investigator.; 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Panaccio P investigator.; Esposito LM investigator.; D'Ascanio F investigator.; Pietroletti R investigator.; Picciariello A investigator.; Chetta N investigator.; Aquilino F investigator.; Di Marco F investigator.; Amico A investigator.; Schembari E investigator.; Puglisi S investigator.; Licari L investigator.; Campanella S investigator.; Profita G investigator.; Falco N investigator.; Rotolo G investigator.; Venturelli P investigator.; Tutino R investigator.; De Marco P investigator.; Marcianò M investigator.; Sgrò A investigator.; Argenti F investigator.; Milani MS investigator.; Malabarba S investigator.; Giambartolomei G investigator.; Vella I investigator.; Gronchi F investigator.; Ruggieri A investigator.; Sancini G investigator.; Roggiani A investigator.; Balsamo F investigator.; Gori A investigator.; Cuicchi D investigator.; D'Alessio R investigator.; Benvenuto D investigator.; Gordini L investigator.; Erdas E investigator.; Podda F investigator.; Cappellacci F investigator.; Salaris C investigator.; Sanna S investigator.; Marcialis J investigator.; Mosino L investigator.; Peddis M investigator.; Melis S investigator.; De Donno G investigator.; Aru AC investigator.; Falsetti E investigator.; Parini D investigator.; Lanari J investigator.; D'Errico U investigator.; Bianchini S investigator.; Birindelli A investigator.; Figà F investigator.; Caiazzo A investigator.; Selvaggi L investigator.; Capozzolo A investigator.; Cerra C investigator.; Pirillo M investigator.; Papandrea M investigator.; Cravano S investigator.; Libri I investigator.; Laquatra N investigator.; Isabello A investigator.; Truškovs A investigator.; Bartnick A investigator.; Malcevs E investigator.; Machatschek MJ investigator.; Alm J investigator.; Lapsa S investigator.; Delorme M investigator.; Zeynalov F investigator.; Larnovskis J investigator.; Sauka J investigator.; Bodrov D investigator.; Gailumsis R investigator.; Wiemann AM investigator.; Müller NL investigator.; Jelovskis I investigator.; 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te Molder L investigator.; Tromp J investigator.; Matthee E investigator.; Tissen YM investigator.; Brinkhuis E investigator.; de Vries HS investigator.; 't Hart E investigator.; Beckers K investigator.; Bekker Y investigator.; Kakar S investigator.; ten Doesschate SFH investigator.; van Smaalen TC investigator.; Veen OC investigator.; Dingemans SA investigator.; van den Brink LC investigator.; Vijgen GHEJ investigator.; van de Voort EMF investigator.; van der Pool A investigator.; van Rest KLC investigator.; Haak T investigator.; Sluijpers NRF investigator.; Pruijssers SR investigator.; Molenaar CJL investigator.; Gordinou de Gouberville MC investigator.; Saleh S investigator.; Mens MA investigator.; Hoeks EM investigator.; Nieuwenhuizen S investigator.; van Praag EM investigator.; Westerduin E investigator.; Smit MPCM investigator.; van der Lely SJ investigator.; Nasimi B investigator.; Gerdsen M investigator.; Stijns RCH investigator.; Leow TYS investigator.; Penningnieuwland G investigator.; de Ruiter A investigator.; Ribbers T investigator.; Aarts CAM investigator.; Tulek MS investigator.; de Jonge J investigator.; Kocak S investigator.; Alqethami HJ investigator.; Constansia R investigator.; van Elst PC investigator.; Tissink MW investigator.; Grüter A investigator.; Vroom Y investigator.; Voeten DM investigator.; Feenstra T investigator.; Azzahhafi J investigator.; Bofarid S investigator.; Kip M investigator.; Saleh W investigator.; Franssen S investigator.; Boon CL investigator.; Franssen RJM investigator.; Romaen I investigator.; Jense MTF investigator.; D'Souza J investigator.; Pascoe R investigator.; Scott A investigator.; Stark E investigator.; Mulholland K investigator.; Lau WK investigator.; Smith B investigator.; Adams SIB investigator.; Shah N investigator.; Ling E investigator.; Young J investigator.; Peng SL investigator.; Jacobson A investigator.; Macfater H investigator.; Farik S investigator.; Chen SY investigator.; Kilpatrick K investigator.; Kim DH investigator.; Dixon S investigator.; Yassaie S investigator.; Welman D investigator.; Coulter J investigator.; Morreau M investigator.; Li E investigator.; Rankin A investigator.; Winders J investigator.; Skipworth C investigator.; Fagan PVB investigator.; Stanfield B investigator.; Henderson N investigator.; Chuang A investigator.; Maskill L investigator.; Ker H investigator.; McLaughlin SJP investigator.; Kearney J investigator.; Wilton S investigator.; Sprosen H investigator.; Kerckhoffs P investigator.; Alsadat R investigator.; Cherry R investigator.; Chapman DA investigator.; Singh N investigator.; Clucas A investigator.; Gatenby G investigator.; Kelly B investigator.; Ruppeldt P investigator.; McIntosh ND investigator.; Koh S investigator.; Wilms H investigator.; Dalzell F investigator.; Tewhaiti‐Smith J investigator.; Kader T investigator.; Yam ST investigator.; Dahya D investigator.; Hardie Boys M investigator.; Fleischl W investigator.; Tan J investigator.; Skavysh A investigator.; Mouldey K investigator.; Elliott BM investigator.; Hu R investigator.; Edwards S investigator.; Matthews C investigator.; Aitken E investigator.; Walker M investigator.; Guerreiro I investigator.; Tomé M investigator.; Patrocinio S investigator.; Amado F investigator.; Batista A investigator.; Seabra J investigator.; Praxedes V investigator.; Monteiro N investigator.; Martins I investigator.; Serra ML investigator.; Santos TC investigator.; Lages RR investigator.; Pimentel A investigator.; Machado ND investigator.; Sá TC investigator.; Bernardes FM investigator.; Saraiva P investigator.; Almeida J investigator.; Mendes M investigator.; Fernandes V investigator.; Ribeiro A investigator.; Soares D investigator.; Costa M investigator.; Rosete M investigator.; Martins T investigator.; Miguel I investigator.; Martins J investigator.; Cunha MF investigator.; Melo J investigator.; Veiga DN investigator.; Rachadell J investigator.; Amorim E investigator.; Vareda R investigator.; Roseira J investigator.; Catarino S investigator.; Aveiro D investigator.; Couto M investigator.; Loureiro AR investigator.; Louro H investigator.; Queiros T investigator.; Castro B investigator.; Fonseca S investigator.; Carvalho L investigator.; Torre AP investigator.; Amado A investigator.; Leite M investigator.; Miranda P investigator.; Cunha C investigator.; Ferreira M investigator.; Cavadas D investigator.; Silva R investigator.; Pina S investigator.; Paixão I investigator.; Orelhas L investigator.; Santos J investigator.; Pacheco A investigator.; Rocha AF investigator.; Jervis MJ investigator.; Pedro V investigator.; Paixão V investigator.; Guerreiro A investigator.; Melo D investigator.; Correia D investigator.; Capella V investigator.; Moinhos T investigator.; Monteiro C investigator.; Silva M investigator.; Vieira BN investigator.; Silva AG investigator.; Galvão D investigator.; Mora A investigator.; Bettencourt R investigator.; Costa F investigator.; Gil I investigator.; Morgado J investigator.; Neves J investigator.; Mónica I investigator.; Oliveira S investigator.; Ribeiro H investigator.; Ferreira M investigator.; Guimarães N investigator.; Duarte M investigator.; Miranda J investigator.; Martins SF investigator.; Almeida MR investigator.; Parreira R investigator.; Faustino A investigator.; Medeiros N investigator.; Castro R investigator.; Soares B investigator.; Resendes M investigator.; Almeida P investigator.; Cruz A investigator.; Claro M investigator.; Vaz Pinto G investigator.; Sousa D investigator.; Costa Santos D investigator.; Silva A investigator.; Silva F investigator.; Fialho G investigator.; Reia M investigator.; Pratas N investigator.; Capote H investigator.; Costa C investigator.; Costa J investigator.; Morais S investigator.; Machado A investigator.; Horta V investigator.; Rocha‐Melo M investigator.; Patrício J investigator.; Pereira M investigator.; Lima R investigator.; Cinza AM investigator.; Oliveira J investigator.; Velez C investigator.; Ferreira M investigator.; Borges F investigator.; Simões J investigator.; Eiró F investigator.; Botelho P investigator.; Cismasiu B investigator.; Alves D investigator.; Dias B investigator.; Costa C investigator.; Gonçalves JP investigator.; Valente P investigator.; Oliveira J investigator.; Freire L investigator.; Saraiva R investigator.; Moreira M investigator.; Fragoso M investigator.; Guimarães J investigator.; Cruz G investigator.; Aparício DJ investigator.; Ribeiro J investigator.; Borges da Ponte I investigator.; Almeida S investigator.; Martins AR investigator.; Louro T investigator.; Morgado M investigator.; Ferreira AS investigator.; Alves M investigator.; Oliveira N investigator.; Lérias R investigator.; Neves‐Marques C investigator.; Estalagem I investigator.; Botelho C investigator.; Bártolo J investigator.; Fidalgo Antunes C investigator.; Cabral F investigator.; Brito Silva F investigator.; Dias Matos A investigator.; Santos M investigator.; Cunha R investigator.; Duarte M investigator.; Sousa M investigator.; Canotilho R investigator.; Peyroteo M investigator.; Correia AM investigator.; Martins PC investigator.; Jardim JAM investigator.; Domingos SP investigator.; Baião JM investigator.; Rocha BS investigator.; Lopes NMRO investigator.; Jordão DM investigator.; Correia JG investigator.; Ângelo MD investigator.; Caroço T investigator.; Romano M investigator.; Gomes JR investigator.; Monteiro RG investigator.; Varghese S investigator.; Boyle E investigator.; Aljohmani L investigator.; Alexander J investigator.; Graziadei V investigator.; McCaughey C investigator.; Jain A investigator.; Lee J investigator.; Ramanayake H investigator.; Sabnani R investigator.; Colon LF investigator.; Bansal N investigator.; Stephens I investigator.; Tan R investigator.; Sharma S investigator.; Doherty G investigator.; Fenn S investigator.; Mulhare E investigator.; Walsh M investigator.; Leavey C investigator.; Costigan O investigator.; Griffin S investigator.; Dockry é investigator.; Khogali E investigator.; Aly AK investigator.; McPhedran R investigator.; O'Gorman D investigator.; Vermeulen D investigator.; Dervan L investigator.; Kang SJ investigator.; Dixon O investigator.; Morrissey E investigator.; Compton M investigator.; Pentony AR investigator.; Piong CL investigator.; Nossier R investigator.; Hanna J investigator.; Sabir K investigator.; Eow SY investigator.; Ladak N investigator.; Boersma D investigator.; Kamath PJ investigator.; Soh TBW investigator.; Dyer AH investigator.; Chee SY investigator.; Tan IXH investigator.; Kelliher A investigator.; Adeusi L investigator.; Howarth N investigator.; McCawley N investigator.; O'Neill A investigator.; Jones MR investigator.; Saleh R investigator.; Singh A investigator.; Senaratne R investigator.; Kakodkar P investigator.; Balasubramanian I investigator.; Hogan A investigator.; Al‐Salihi A investigator.; Vyas V investigator.; Vedadi A investigator.; Popescu SS investigator.; Piras K investigator.; Ciubotaru CI investigator.; Litvin A investigator.; Romanova E investigator.; Ponomarev N investigator.; Savchenko A investigator.; Yanishev A investigator.; Luzan R investigator.; Lutovinova E investigator.; Gavrilina A investigator.; Barkovskaya A investigator.; Kudelkina N investigator.; Topchubaev D investigator.; Radulović R investigator.; Miloševic K investigator.; Ćuk VV investigator.; Bojičić J investigator.; Juloski J investigator.; Genčić M investigator.; Janković U investigator.; Zubowicz M investigator.; Sucháň PK investigator.; Gerstmeier J investigator.; Mészárosová K investigator.; Brazitikou E investigator.; Fytrou E investigator.; Celik M investigator.; Dubovský M investigator.; Schmalenbeck J investigator.; Sautter SC investigator.; Ceyran H investigator.; Jaich R investigator.; Fitchat N investigator.; Mathebula S investigator.; Chauke J investigator.; Mculu W investigator.; Ngwenya Z investigator.; Withey K investigator.; Piperidis A investigator.; Toyi Y investigator.; Nicolaides A investigator.; Jaffer T investigator.; Sparke A investigator.; Van Staden N investigator.; McDuling CR investigator.; Claassen L investigator.; Kruger C investigator.; Weyers J investigator.; Marx M investigator.; Lecler J investigator.; Mignon G investigator.; Vanoni A investigator.; Henkens A investigator.; Jarrar G investigator.; Odovic M investigator.; Willemin M investigator.; Milliet O investigator.; Hahnloser D investigator.; Clerc D investigator.; Demartines N investigator.; Piazza G investigator.; Teixeira H investigator.; Pittet O investigator.; Haller ML investigator.; Gagliardi B investigator.; Huot A investigator.; Blaser B investigator.; Kefleyesus A investigator.; Bugmann A investigator.; Piotet LM investigator.; Meijers L investigator.; Kurtoglu GK investigator.; Sel EK investigator.; Isler VC investigator.; Yilmaz BS investigator.; Adiyaman C investigator.; Kara M investigator.; Demirkaya HC investigator.; Korkmaz HK investigator.; Pektas AM investigator.; Güner B investigator.; İşlek EC investigator.; Tombul HB investigator.; Boztuğ CY investigator.; Tınaz A investigator.; Yılmaz M investigator.; Karaman Y investigator.; Akın FA investigator.; Dansuk S investigator.; Başçavuş M investigator.; Kaya M investigator.; Kutlu B investigator.; Seker MC investigator.; Erten V investigator.; Memis U investigator.; Koçak ZB investigator.; Karapinar YE investigator.; Fakirullahoglu M investigator.; Uslu Ö investigator.; Köseoglu E investigator.; Yeni M investigator.; Aktas MK investigator.; Aykun N investigator.; Agca MH investigator.; Bilen C investigator.; Kilinc I investigator.; Atar C investigator.; Kilic V investigator.; Aktuna C investigator.; Aba M investigator.; Alim YE investigator.; Binbuga M investigator.; Kürklü Ö investigator.; Yurdaor SS investigator.; Ceylan C investigator.; Yilmaz S investigator.; Çalar SN investigator.; Yildirim N investigator.; Yavuz G investigator.; Yagız Sen A investigator.; Can B investigator.; Cesmeli E investigator.; Kus D investigator.; Kavar RC investigator.; Cevlik AD investigator.; Cengiz U investigator.; Turk EG investigator.; Yilmaz I investigator.; Yüksek B investigator.; Erdönmez H investigator.; Gürsoy F investigator.; Serin H investigator.; Kara H investigator.; Önsal U investigator.; Özbek M investigator.; Kasar PA investigator.; Ipor A investigator.; Özen D investigator.; Ölmez M investigator.; Altintas E investigator.; Kaya Y investigator.; Toklu R investigator.; Sariçiçek T investigator.; Tipi OU investigator.; Benli GE investigator.; Tasdelen I investigator.; Tura A investigator.; Ucar A investigator.; Ekci B investigator.; Bilgili AC investigator.; Kiraz IN investigator.; Aksoy H investigator.; Cinar EN investigator.; Basak A investigator.; Erdem M investigator.; Kayacan S investigator.; Sahin C investigator.; Uysal M investigator.; Karakus K investigator.; Altiner S investigator.; Demirci ZS investigator.; Eren E investigator.; Yavas M investigator.; Tiftik E investigator.; Aksoy AB investigator.; Karagöz E investigator.; Sabanci R investigator.; Tümer SS investigator.; Kargici K investigator.; Banaz T investigator.; Abdulrahman SMF investigator.; Yesilsancak M investigator.; Yanikoglu E investigator.; Karabulut A investigator.; Yilmaz D investigator.; Kuyumcu OF investigator.; Kutluk F investigator.; Emiroglu B investigator.; Aksoy B investigator.; Mollavelioglu B investigator.; Gereklioglu D investigator.; Guler M investigator.; Toprak S investigator.; Afsar HB investigator.; Guler SE investigator.; Alizade E investigator.; Baki BE investigator.; Alemdag G investigator.; Ulusahin M investigator.; Arslan E investigator.; Gul EB investigator.; Yildirim R investigator.; Semiz A investigator.; Bektur G investigator.; Tomas K investigator.; Bilicen G investigator.; Yarenci E investigator.; Demiroglu Y investigator.; Sunal A investigator.; Baykan B investigator.; Abbasguliyev H investigator.; Mutlu V investigator.; Mahmoudi Y investigator.; Dossa SAA investigator.; Mizan SR investigator.; Demirtas B investigator.; Cavus T investigator.; Yuksek A investigator.; Mazlum SS investigator.; Yelkenci C investigator.; Baran T investigator.; Satilmisoglu M investigator.; Sahin AZ investigator.; Kilinç A investigator.; Isik K investigator.; Yumurtaci Ö investigator.; Emin A investigator.; Girit Çagri investigator.; Yildirak MK investigator.; Senyigit E investigator.; Güldag A investigator.; Söyleyici B investigator.; Aytin YE investigator.; Akay FE investigator.; Iskan NG investigator.; Mutlu B investigator.; Sunay AO investigator.; Ablett AD investigator.; Tie‐Gill T investigator.; Ramsay G investigator.; De Paola L investigator.; McGuckin S investigator.; Alshakhs A investigator.; Ahmeidat A investigator.; Wong J investigator.; Goergen N investigator.; Ali Z investigator.; Mullarkey L investigator.; Bath MF investigator.; Walshe R investigator.; Lewis E investigator.; Berry B investigator.; Moneim J investigator.; Mookerjee S investigator.; Christy S investigator.; Ojofeitimi O investigator.; Carroll L investigator.; Hylands A investigator.; Delaugere LP investigator.; Reveendran D investigator.; Coulter C investigator.; Ralston C investigator.; Laverty L investigator.; Gallagher P investigator.; Ahmed A investigator.; Yeo YQ investigator.; Elliott D investigator.; Bennett J investigator.; Mcnamara M investigator.; Sivarajah S investigator.; Dunmore C investigator.; Aitken G investigator.; Nair M investigator.; Aly MH investigator.; Buari M investigator.; Farhan‐Alanie MMH investigator.; Ahmed K investigator.; Sheikh Z investigator.; Monks M investigator.; Lehmann J investigator.; Rotimi O investigator.; Bell T investigator.; Limnatitou D investigator.; Gormley S investigator.; Taleongpong P investigator.; Patel V investigator.; Macgregor L investigator.; Amini S investigator.; Turner C investigator.; Dwyer‐Hemmings L investigator.; Busuttil A investigator.; Powell J investigator.; Hensher C investigator.; Vivian F investigator.; Wcislo K investigator.; Millar Z investigator.; Hirosue S investigator.; Ogunmwonyi I investigator.; Nakakande D investigator.; Kwek I investigator.; Gaze H investigator.; Nirmalanantha A investigator.; Bin Amran AM investigator.; Foulkes A investigator.; Jones N investigator.; Pillai S investigator.; Khoury G investigator.; Powell T investigator.; Maleyko I investigator.; Sangheli A investigator.; Ransome M investigator.; Isse M investigator.; Aromolaran O investigator.; Bholah H investigator.; Anbarasan J investigator.; Rehman S investigator.; Hu E investigator.; Timms S investigator.; Reynolds W investigator.; Hotchkies A investigator.; Misra V investigator.; Suresh G investigator.; Murray V investigator.; Theocharidou L investigator.; Malik T investigator.; Janmohamed I investigator.; Carhart B investigator.; Khan A investigator.; Asif A investigator.; Hullait R investigator.; Quinn P investigator.; Rylance A investigator.; Butt S investigator.; Leathes J investigator.; Finch BJ investigator.; Philip Rajathasan T investigator.; Jeddy H investigator.; Kyaw HA investigator.; Wong N investigator.; Karelia S investigator.; Clements JM investigator.; Rainey M investigator.; Joshi N investigator.; Rahman A investigator.; Gallagher M investigator.; Rebuffa N investigator.; Abdelgalil R investigator.; Siaw Yen Lai R investigator.; Laurence N investigator.; Thomas S investigator.; Green C investigator.; Frostick R investigator.; Khera R investigator.; Povey M investigator.; Wong HL investigator.; McCusker C investigator.; Hlukha L investigator.; Pike G investigator.; Kamel F investigator.; Thakkar R investigator.; Donaldson C investigator.; Sequeira Campos M investigator.; Bhahirathan Y investigator.; Armitage MN investigator.; Hussain AS investigator.; Hardy B investigator.; Hassan Serry MY investigator.; Herron J investigator.; Bradbury M investigator.; Osunronbi T investigator.; Tam LYC investigator.; Khanan Kaabneh A investigator.; Lawther J investigator.; Fisher P investigator.; Tribedi T investigator.; Moosa A investigator.; Ramdin A investigator.; Goble M investigator.; Downs E investigator.; Wheldon L investigator.; Baggus E investigator.; Mandal A investigator.; Nayeem A investigator.; Ahmed S investigator.; Fradley W investigator.; Wilson C investigator.; Gallagher S investigator.; Criswell T investigator.; Ward J investigator.; Mukkavilli A investigator.; Stubbs B investigator.; Fordyce W investigator.; Suchdev N investigator.; Wei Lim S investigator.; Yi Tew Z investigator.; Sookramanien SR investigator.; Chan A investigator.; Bointas G investigator.; Paul M investigator.; Ward KL investigator.; Bagnall M investigator.; Pherwani SA investigator.; Wang K investigator.; Mitchell L investigator.; Heyworth J investigator.; Ayyar S investigator.; Obukofe R investigator.; Polson R investigator.; Mason D investigator.; Mackenzie E investigator.; Russell C investigator.; Doyle N investigator.; Habib Z investigator.; Zardab M investigator.; Sartaj F investigator.; Farooq H investigator.; Tabibi M investigator.; Drury DJ investigator.; James SJ investigator.; Barnett R investigator.; Teasdale AB investigator.; Richardson ETJ investigator.; Thomas DA investigator.; Ahmed S investigator.; Williams RL investigator.; Najabat‐Lattif HF investigator.; Cahya E investigator.; Lou G investigator.; Coyle M investigator.; Homyer K investigator.; Zhu LY investigator.; Woods M investigator.; Chang J investigator.; O'Callaghan H investigator.; Suchett‐Kaye I investigator.; Mihailidis TH investigator.; Alawattegama H investigator.; Seite E investigator.; Barrett A investigator.; Riordan E investigator.; Lam W investigator.; Dowdeswell M investigator.; Mulvenna C investigator.; Netke T investigator.; Awokoya O investigator.; Gurowich L investigator.; Dhera K investigator.; Hayat S investigator.; Williams L investigator.; Tincknell L investigator.; Spazzapan M investigator.; Teeling F investigator.; Sysum K investigator.; Latter J investigator.; Latter M investigator.; Khan S investigator.; Guruswamy M investigator.; Beedham W investigator.; Brazier E investigator.; Elghobashy M investigator.; Bajaj M investigator.; Mann H investigator.; Etel E investigator.; Woodmass M investigator.; Hayden H investigator.; Kisiel A investigator.; Ali Y investigator.; Husain S investigator.; Arnold A investigator.; Pedersen AC investigator.; Cunha P investigator.; Ahmed M investigator.; Al Zawawi S investigator.; Kudva V investigator.; Liu FY investigator.; Theodoropoulou K investigator.; Miscampbell M investigator.; Robinson AV investigator.; Johnston J investigator.; Dharni A investigator.; Lamb S investigator.; Westerman T investigator.; Evans E investigator.; Campbell L investigator.; Gillespie M investigator.; Cheong CM investigator.; Kulathevanayagam K investigator.; Varghese A investigator.; Ike SI investigator.; Chu TSM investigator.; Baljer B investigator.; Mogg JAW investigator.; Rai P investigator.; Claireaux HA investigator.; Williams M investigator.; Smillie R investigator.; Goetz J investigator.; Appleby E investigator.; Fadipe T investigator.; Vaughan‐Burleigh S investigator.; Puri G investigator.; Hussain P investigator.; James P investigator.; Flather R investigator.; Cutler A investigator.; Pathak S investigator.; Sheldon J investigator.; Collicott T investigator.; al‐Ausi M investigator.; Mondal A investigator.; Jovaisaite A investigator.; Shah SM investigator.; Khalid N investigator.; Gutmann D investigator.; Davison S investigator.; Alame YJ investigator.; Syed L investigator.; Owen WJ investigator.; Ahsan SD investigator.; Kalderon R investigator.; Anthony‐Uzoeto U investigator.; Macleod Hall C investigator.; Zheng S investigator.; Wynter K investigator.; James C investigator.; Sapre D investigator.; Ghosh R investigator.; Baird J investigator.; Cockburn L investigator.; Blackwood O investigator.; Nadama HH investigator.; Simpson W investigator.; Jeong S investigator.; Bishop S investigator.; Bate R investigator.; Hobson C investigator.; Adam AH investigator.; Redclift C investigator.; Do J investigator.; Adeleye O investigator.; Poli F investigator.; Batterham A investigator.; Brown S investigator.; Parekh JN investigator.; Clay W investigator.; Pieri K investigator.; Jackson A investigator.; Brown S investigator.; Saxena A investigator.; Gurung B investigator.; Oyebola T investigator.; O'Brien F investigator.; Djeugam B investigator.; Gardezi S investigator.; Ul‐Hasan S investigator.; Martin‐Hernandez MP investigator.; Sisley M investigator.; Modi S investigator.; Antakia R investigator.; Elbayouk A investigator.; Soh YJ investigator.; Mather J investigator.; Yusuf Z investigator.; Al‐Sarraf Z investigator.; Naja M investigator.; Rassool SB investigator.; Convill J investigator.; Nikookam Y investigator.; Warsame A investigator.; Tam JPH investigator.; Pace C investigator.; Kiandee M investigator.; Ridwan R investigator.; Carey C investigator.; Hirri F investigator.; McMillan MJA investigator.; Ling JJ investigator.; Powell‐Chandler A investigator.; Pendelbury L investigator.; Kerimzade K investigator.; Tang A investigator.; Howard EO investigator.; Humayun S investigator.; Wadsworth OJ investigator.; Tan K investigator.; Abdelhameed F investigator.; Haglund C investigator.; Radnaeva I investigator.; Hu N investigator.; Rambhatla S investigator.; Waldron D investigator.; Madahar P investigator.; Malik S investigator.; Campbell A investigator.; Meney LC investigator.; Ibrahim I investigator.; Kang CK investigator.; Chiu JZJ investigator.; Livie V investigator.; Ibrahim B investigator.; Khalil M investigator.; Pooley G investigator.; Shishkin B investigator.; Gorgievska R investigator.; Docherty J investigator.; Southgate A investigator.; Coomes A investigator.; McGee F investigator.; Flanagan S investigator.; Thakrar C investigator.; Tan QJ investigator.; Anwar H investigator.; Clough R investigator.; Chrisp B investigator.; Cassels J investigator.; Cross GWV investigator.; Ragavoodoo A investigator.; Mercer L investigator.; Mercer C investigator.; Refalo A investigator.; Hadley R investigator.; McTighe A investigator.; Farrow F investigator.; Brodie A investigator.; Davis G investigator.; Shah DR investigator.; Bowers C investigator.; Patel S investigator.; Morice O investigator.; Burzic A investigator.; Cheung J investigator.; Shashidhara A investigator.; Theodoraki G investigator.; Birk J investigator.; Ong A investigator.; Ng MPE investigator.; Wong RTW investigator.; Maese S investigator.; Yeap B investigator.; Iqbal Z investigator.; Rojoa DM investigator.; Cabaleiro Barciela C investigator.; Hussain M investigator.; Ruddy CM investigator.; Lindwe S investigator.; Qamar Y investigator.; Chuita S investigator.; Melaugh T investigator.; Hall JD investigator.; Palmer C investigator.; Kouli O investigator.; Hassane ASI investigator.; Azhar AW investigator.; Tan TK investigator.; Perchard W investigator.; Scurr T investigator.; Davidson K investigator.; Campbell E investigator.; Kelk L investigator.; Ghosh A investigator.; Gibbins A investigator.; Mala D investigator.; Loizidou A investigator.; Hall O investigator.; Mecia L investigator.; Hew C investigator.; Varathan K investigator.; Tong L investigator.; Chandrasekar B investigator.; Giacci L investigator.; Buchanan E investigator.; O'Connell M investigator.; Kwak SY investigator.; Ong EH investigator.; Gardner S investigator.; Lim J investigator.; Maden C investigator.; Illahi M investigator.; Hale J investigator.; Xuan Tan Z investigator.; Edwards S investigator.; Stahl R investigator.; Stahl J investigator.; Hickman A investigator.; Collett D investigator.; Goolam‐Mahomed Z investigator.; Allen B investigator.; Atiyah A investigator.; Ahmad H investigator.; Jones J investigator.; McGregor O investigator.; Ogundiya E investigator.; Gan FW investigator.; Boulbadaoui A investigator.; Kirnon‐Jackman O investigator.; Lim QX investigator.; Peckham H investigator.; Yeoh T investigator.; Yong SQ investigator.; Chen JY investigator.; Siva S investigator.; Sam ZH investigator.; Gilani M investigator.; Goh YN investigator.; Muthukumar MG investigator.; Phillips S investigator.; Makin‐Taylor R investigator.; Tjoakarfa J investigator.; Giri A investigator.; Suresan S investigator.; Thavayogan R investigator.; Hey CY investigator.; Thomas P investigator.; Johnson TA investigator.; Williams RI investigator.; Rashid A investigator.; Kushairi A investigator.; Rais A investigator.; James A investigator.; Bugelli M investigator.; Chechelnitskaya Y investigator.; Sandhu N investigator.; Toh C investigator.; Tandon R investigator.; Gray M investigator.; Kumar A investigator.; Ciurleo C investigator.; Nyamali I investigator.; Hiremath S investigator.; Sinha S investigator.; Chowdhary M investigator.; Bradley E investigator.; McTiernan M investigator.; Macdonald S investigator.; Sharkey S investigator.; McLaughlin N investigator.; Amey C investigator.; Kraria L investigator.; Skan O investigator.; Kind C investigator.; Findlay JM investigator.; Tupper P investigator.; Van Rhee C investigator.; Honeyman SI investigator.; Menon G investigator.; Ahmed M investigator.; Jegatheeswaran L investigator.; Griffiths N investigator.; Madhavan A investigator.; Warne M investigator.; Malcolm FL investigator.; Lessware T investigator.; Wilkerson HT investigator.; Chatterjee‐Woolman S investigator.; Yoong A investigator.; Ahmed WUR investigator.; Longshaw A investigator.; Flannery O investigator.; Green R investigator.; Leaning M investigator.; Cragg J investigator.; Sharriff H investigator.; Doherty C investigator.; Ganesananthan S investigator.; Kwan KWL investigator.; Sanders‐Crook L investigator.; Bhatia S investigator.; Eames S investigator.; Lewis F investigator.; Kirupananthan P investigator.; Boh ZY investigator.; Dass S investigator.; Soma A investigator.; Newton A investigator.; Hill M investigator.; Shafiq Y investigator.; Brkljac M investigator.; Boyce L investigator.; Jasionowska S investigator.; English WJ investigator.; Lam S investigator.; Chipeta C investigator.; Yilmaz D investigator.; Jain C investigator.; Garofalidou T investigator.; Novotny SA investigator.; Locke S investigator.; Bowman C investigator.; Begaj A investigator.; Murphy C investigator.; Radcliffe K investigator.; Chong JT investigator.; Poustie M investigator.; Jeffrey E investigator.; Chaudhury N investigator.; Rajendran K investigator.; Akbar Z investigator.; Walters B investigator.; Kulendrarajah B investigator.; Tran N investigator.; Shrestha S investigator.; Parmar S investigator.; Gallagher C investigator.; Hennessy L investigator.; Pentti E investigator.; Badhrinarayanan S investigator.; Fung A investigator.; Mansoor M investigator.; Kenny R investigator.; Kan P investigator.; Lee DE investigator.; Khosla S investigator.; Samake M investigator.; Shaban F investigator.; Aftab R investigator.; Gough M investigator.; Woodburn B investigator.; Vayalapra S investigator.; McMurrugh K investigator.; Wong C investigator.; Jimulia D investigator.; Deol S investigator.; Pike S investigator.; Embury‐Young Y investigator.; Turner T investigator.; Patel M investigator.; Kilgallon E investigator.; Keating R investigator.; Walsh A investigator.; Khan H investigator.; Logue G investigator.; Orekoya M investigator.; Alasmar M investigator.; Charalambides M investigator.; Clavé Llavall A investigator.; Williamson E investigator.; Bharwada Y investigator.; Zearmal S investigator.; Evans H investigator.; Panikkar M investigator.; de la Cruz G investigator.; Caplan J investigator.; Ruparelia A investigator.; Tanvir T investigator.; Soare C investigator.; Pang YL investigator.; Trotter J investigator.; Zaidi A investigator.; Thakrar V investigator.; Pulickal P investigator.; Ahmed H investigator.; Parnell J investigator.; Khan H investigator.; Lennock S investigator.; Ford V investigator.; Pyc W investigator.; Brignall R investigator.; O'Neill D investigator.; Hanna R investigator.; Kane R investigator.; Nicola M investigator.; Rajput K investigator.; Xiao Y investigator.; Warner C investigator.; Michael S investigator.; Wright E investigator.; Juniper S investigator.; Thompson E investigator.; Hoskyns L investigator.; Kanitkar A investigator.; Ross C investigator.; Unsworth A investigator.; Rshaidat H investigator.; Demarre K investigator.; Chiang A investigator.; Bareh A investigator.; van Dellen J investigator.; Faqihinejad C investigator.; Gadhvi A investigator.; Grant R investigator.; Lewsey J investigator.; Morris A investigator.; Martin H investigator.; McClarty C investigator.; Sanyal S investigator.; Alsaif A investigator.; Palkhi A investigator.; Bhopal S investigator.; Vishnu K S investigator.; Papanikolaou A investigator.; Mitra A investigator.; Nur A investigator.; Ali F investigator.; Burford C investigator.; Huq T investigator.; Sloper W investigator.; Irwin E investigator.; Matthews L investigator.; Ngu WS investigator.; Hosfield T investigator.; Muneeb F investigator.; Page O investigator.; Zeb E investigator.; Coey J investigator.; Al‐Azzawi A investigator.; McIntosh J investigator.; Vucicevic A investigator.; Hughes M investigator.; Brooks L investigator.; Fanibi B investigator.; Dixon M investigator.; Njoku P investigator.; Morris D investigator.; Jobson J investigator.; Chowdhury H investigator.; Alawode DOT investigator.; Wynell‐Mayow W investigator.; Udayachandran V investigator.; Alsoof D investigator.; Ekert J investigator.; Joseph N investigator.; Zulkefley N investigator.; Hunt G investigator.; Christodoulou T investigator.; Wright O investigator.; Soman S investigator.; Jamal M investigator.; Beqiri S investigator.; Borgas P investigator.; Christie S investigator.; Pereira F investigator.; Browne S investigator.; Yiu J investigator.; Dworkin A investigator.; Brayley J investigator.; Palmer A investigator.; Charalambos M investigator.; Jones CS investigator.; Toner S investigator.; Cowden R investigator.; Lee L investigator.; Nicol P investigator.; Holman O investigator.; Imtiaz M investigator.; Albert V investigator.; Leung SP investigator.; Erotocritou M investigator.; Wong J investigator.; Stroud R investigator.; Mason D investigator.; Wilkin R investigator.; Thomson W investigator.; Mackee L investigator.; G N investigator.; Bei Y investigator.; Sait S investigator.; Mckenna Favier S investigator.; Ibrahim A investigator.; Kler A investigator.; Reynolds L investigator.; Mohamed SH investigator.; Majeed Y investigator.; Fakim B investigator.; Jones A investigator.; Kowal M investigator.; Liversedge G investigator.; Carrington Z investigator.; Windebank J investigator.; Izzarina A investigator.; Akbani U investigator.; Craven J investigator.; Aldarragi A investigator.; Harding S investigator.; Millward A investigator.; Shortland TC investigator.; Bedford M investigator.; Stroud R investigator.; Obukofe R investigator.; Mackenzie E investigator.; Gopalan V investigator.; Midgen A investigator.; Khadka P investigator.; Cheng O investigator.; Taneja S investigator.; Manobharath N investigator.; Kok JY investigator.; Lim DWE investigator.; Buick T investigator.; Boland M investigator.; Piya S investigator.; Devlin R investigator.; Fairfield CJ investigator.; George RJ investigator.; Rahi M investigator.; Zaman S investigator.; Hajiev S investigator.; Ross T investigator.; Owen M investigator.; Crisp E investigator.; Thompson C investigator.; Charalambous A investigator.; Hollywood JL investigator.; Saiyed A investigator.; Hammond RFL investigator.; Matthews J investigator.; Mendonca V investigator.; Spinty J investigator.; Khan K investigator.; Cheng J investigator.; Glynn N investigator.; Muhammad U investigator.; Khan M investigator.; Anderson L investigator.; Mccormack K investigator.; Mak J investigator.; Patrawala S investigator.; Milinkovic N investigator.; Schofield R investigator.; Chauhan M investigator.; Hartley L investigator.; Hind J investigator.; Ashworth I investigator.; Nelson L investigator.; Ratnasingham D investigator.; Akbari K investigator.; Whitehead T investigator.; Dimitriadis S investigator.; Marshall K investigator.; Flint EJ investigator.; Curran M investigator.; Horner C investigator.; Heybourne A investigator.; Morgan H investigator.; Wickstone C investigator.; Panagiotou D investigator.; O'Connell E investigator.; Dean K investigator.; Iqbal R investigator.; Walsh L investigator.; Yu N investigator.; Rana N investigator.; Massie E investigator.; Ng J investigator.; Jung M investigator.; Lee YD investigator.; Harris M investigator.; White S investigator.; Delibegovic S investigator.; Boev B investigator.; Tonchev P investigator.; Prochazka V investigator.; Örhalmi J investigator.; Riško J investigator.; Skalický A investigator.; Chrz K investigator.; Ravn S investigator.; Ojakäär A investigator.; Duchalais E investigator.; Dörr‐Harim C investigator.; Herrle F investigator.; Koutserimpas C investigator.; Giraudo G investigator.; Armellini A investigator.; Ruzzenente A investigator.; Mazzeo C investigator.; De Padua C investigator.; Realis Luc A investigator.; Maroli A investigator.; Giani I investigator.; Cufari ME investigator.; Vitali M investigator.; Ceccarelli G investigator.; Gusai GP investigator.; Quattromani R investigator.; Virgilio E investigator.; Berti S investigator.; Mulas S investigator.; Di Mola FF investigator.; Papagni V investigator.; Tuminello F investigator.; Magnoli M investigator.; Vittori L investigator.; Longheu A investigator.; Loche GA investigator.; Braccio B investigator.; De Luca E investigator.; Resta G investigator.; Ancans G investigator.; Tamosiunas A investigator.; Petrulionis M investigator.; Andrejevic P investigator.; Stellingwerf ME investigator.; Abdulrahman N investigator.; van de Pas KGH investigator.; Thomas G investigator.; Brandsma AM investigator.; Davids J investigator.; Rottier SJ investigator.; de Roy van Zuidewijn D investigator.; Hawkins R investigator.; Ong HI investigator.; Li Y investigator.; Desmond B investigator.; Winstanley J investigator.; Martins M investigator.; Rosete M investigator.; Americano M investigator.; Santos M investigator.; Frade S investigator.; Senhorinho R investigator.; Peixoto R investigator.; Alagoa João A investigator.; Alves‐Vale C investigator.; Lamas M investigator.; O'Connor DB investigator.; Hoo M investigator.; Gopaul A investigator.; Scanlon K investigator.; O'Dwyer N investigator.; Negoi I investigator.; Jovanović M investigator.; Panyko A investigator.; De Lima H investigator.; Van Vuuren S investigator.; Curchod P investigator.; Gaspar S investigator.; Imadalou L investigator.; Mutlu D investigator.; Akyol C investigator.; Uygur FA investigator.; Eray IC investigator.; Biyiklioglu O investigator.; Çetin MF investigator.; Isik AE investigator.; Karip B investigator.; Dogan H investigator.; Sarıgül L investigator.; Tunc E investigator.; Aydin T investigator.; Bodur S investigator.; Karabulut K investigator.; Francis AA investigator.; Al‐hadithi A investigator.; To N investigator.; Lau ISF investigator.; Smith E investigator.; Mahapatra S investigator.; McAuliffe O investigator.; Francis AA investigator.; Imam L investigator.; Akram B investigator.; Hossaini S investigator.; Davies R investigator.; Ko M investigator.; Collins J investigator.; Pandya A investigator.; Reilly S investigator.; Archer J investigator.; Auty C investigator.; Roche CD investigator.; Livie J investigator.; Chaudhry FA investigator.; Ntakomyti E investigator.; Diallo R investigator.; Bylinski T investigator.; Wright J investigator.; Lawday S investigator.; Masiha E investigator.; Tung J investigator.; Shirazi B investigator.; Neilson A investigator.; Epton S investigator.; Patel N investigator.; Trussell S investigator.; Couldrey A investigator.; Donnelly C investigator.; Eftychiou S investigator.;
• Is Part Of: British journal of surgery. Volume 107:Issue 2(2020)
• Page Start: e161
• Page End: e169
• Publication Date: 2019-10-09
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1002/bjs.11326
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract : Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non‐steroidal anti‐inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student‐ and trainee‐led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre‐specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57–75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1–3, of whom 1061 (92·0 per cent) received non‐selective cyclo‐oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P < 0·001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement. Abstract : The aim of this study was to assess the role of non‐steroidal anti‐inflammatory drugs (NSAIDs) for reducing ileus after surgery. NSAIDs did not reduce the time for gastrointestinal recovery, but they were safe and associated with reduced postoperative opioid requirement. No effect on ileus, but reduces opioid need A video abstract is available at https://youtu.be/uex40nmCUuU Abstract : Antecedentes: El ileo es frecuente tras cirugía colorrectal electiva y se asocia con un incremento de los eventos adversos y de la duración de la estancia hospitalaria. El objetivo fue evaluar el papel de los fármacos antiinflamatorios no esteroideos ( non‐steroidal anti‐inflammatory drugs, NSAIDs) para reducir el ileo tras la cirugía. Métodos: Estudio de cohortes prospectivo y multicéntrico efecuado por un grupo colaborativo dirigido por estudiantes y cirujanos en formación. Se incluyeron pacientes adultos sometidos a cirugía colorectal electiva entre enero y abril 2018. El resultado primario fue el tiempo hasta la recuperaciòn gastrointestinal, medido por una variable compuesta de función intestinal y tolerancia a la alimentación oral. El impacto de los NSAIDs se exploró utilizando un análisis de regresión de Cox, que incluía los resultados de una encuesta específica dirigida a los centros sobre la adherencia a los principios de la recuperación intensificada. Los resultados secundarios de seguridad incluyeron la dehiscencia anastomótica y la insuficiencia renal aguda. Resultados: Se incluyeron 4.164 pacientes con una mediana de edad de 68 años (rango intercuartílico: 57‐75; 54, 9% varones). Un total de 1.153 (27, 7%) pacientes fueron tratados con NSAIDs en los días postoperarorios 1‐3, de los cuales 1.061 (92, 0%) recibieron inhibidores no selectivos de la ciclooxigenasa. Tras los ajustes por las diferencias basales, el tiempo medio hasta la recuperación gastrointestinal no difería significativamente entre pacientes que recibieron o no recibieron NSAIDs (4, 6 versus 4, 8 días; cociente de riesgos instantáneos, hazard ratio, HR 1, 04, i.c. del 95%: 0, 96‐1, 12, P = 0, 360). No hubo diferencias significativas en la tasa de dehiscencias anastomóticas (5, 4% versus 4, 6%; P = 0, 349) o insuficiencia renal aguda (14, 3% versus 13, 8%; P = 0, 666) entre los grupos. Sin embargo, significativamente menos pacientes de los que recibieron NSAIDs precisaron una analgesia intensa con opioides (35, 3% versus 56, 7%; P < 0, 001). Conclusión: La administración de NSAIDs no redujo el tiempo hasta la recuperación gastrointestinal tras cirugía colorrectal, pero fueron seguros y se asociaron con una reducción en la necesidad de opioides postoperarorios.