Emergence of Responsive Surface‐Enhanced Raman Scattering Probes for Imaging Tumor‐Associated Metabolites. Issue 12 (27th February 2022)

• Record Type: Journal Article
• Authors: Yin, Hang; Jin, Ziyi; Duan, Wenjia; Han, Bing; Han, Limei; Li, Cong
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-27
• Subjects: stimuli‐responsive probes -- surface‐enhanced Raman scattering -- tumor‐associated metabolites; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202200030
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: As a core hallmark of cancer, metabolic reprogramming alters the metabolic networks of cancer cells to meet their insatiable appetite for energy and nutrient. Tumor‐associated metabolites, the products of metabolic reprogramming, are valuable in evaluating tumor occurrence and progress timely and accurately because their concentration variations usually happen earlier than the aberrances demonstrated in tissue structure and function. As an optical spectroscopic technique, surface‐enhanced Raman scattering (SERS) offers advantages in imaging tumor‐associated metabolites, including ultrahigh sensitivity, high specificity, multiplexing capacity, and uncompromised signal intensity. This review first highlights recent advances in the development of stimuli‐responsive SERS probes. Then the mechanisms leading to the responsive SERS signal triggered by tumor metabolites are summarized. Furthermore, biomedical applications of these responsive SERS probes, such as the image‐guided tumor surgery and liquid biopsy examination for tumor molecular typing, are summarized. Finally, the challenges and prospects of the responsive SERS probes for clinical translation are also discussed. Abstract : Tumor‐associated metabolites, the products of metabolic reprogramming in cancer cells, are valuable in timely evaluating tumor occurrence and progress. This review highlights recent advances in the development of metabolite‐responsive surface‐enhanced Raman scattering (SERS) probes, discusses the mechanisms leading to the responsive signal, introduces biomedical applications of these SERS probes, and forecasts their challenges and perspective in clinical translation.