Mitochondria transplantation/transfer between single cells. Issue 9 (September 2022)

• Record Type: Journal Article
• Authors: Hu, Qin; Lu, Jianfei; Zhang, Xiaohua; Liu, Ran; Yang, Shao-Hua
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 42:Issue 9(2022)
• Page Start: 1748
• Page End: 1750
• Publication Date: 2022-09
• Subjects: Mitochondria -- mitochondrial transfer -- mitochondrial transplantation -- nanosyringe -- revitalization; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X221109685
• Languages: English
• ISSNs: 0271-678X

Abstract

Mitochondrial transplantation/transfer has been increasingly recognized as a potential way for cell and tissue revitalization. In a recent study, Gabelein et al. reported a novel method for single cells mitochondria transplantation using "nanosyringe". This technique combines atomic force microscopy, optical microscopy, and nanofluidics that enable intra- and intercellular organelle micromanipulation and cell-to-cell mitochondria transplantation with up to 95% success rate. The transferred mitochondria fuse to the host mitochondrial network and donor mtDNA incorporate into the recipient mitochondrial genome. The nanosyringe technique provides a novel tool for future mitochondrial research to offer insight into mitochondrial replacement therapy for stroke and fundamental mitochondrial biology.