Combining navigator and optical prospective motion correction for high‐quality 500 μm resolution quantitative multi‐parameter mapping at 7T. Issue 2 (11th April 2022)

• Record Type: Journal Article
• Authors: Vaculčiaková, Lenka; Podranski, Kornelius; Edwards, Luke J.; Ocal, Dilek; Veale, Thomas; Fox, Nick C.; Haak, Rainer; Ehses, Philipp; Callaghan, Martina F.; Pine, Kerrin J.; Weiskopf, Nikolaus
• Is Part Of: Magnetic resonance in medicine. Volume 88:Issue 2(2022)
• Page Start: 787
• Page End: 801
• Publication Date: 2022-04-11
• Subjects: 7T -- FID navigator -- multi‐parameter mapping -- physiological artifacts -- prospective motion correction -- quantitative MRI; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.29253
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: High‐resolution quantitative multi‐parameter mapping shows promise for non‐invasively characterizing human brain microstructure but is limited by physiological artifacts. We implemented corrections for rigid head movement and respiration‐related B0‐fluctuations and evaluated them in healthy volunteers and dementia patients. Methods: Camera‐based optical prospective motion correction (PMC) and FID navigator correction were implemented in a gradient and RF‐spoiled multi‐echo 3D gradient echo sequence for mapping proton density (PD), longitudinal relaxation rate (R1) and effective transverse relaxation rate (R2*). We studied their effectiveness separately and in concert in young volunteers and then evaluated the navigator correction (NAVcor) with PMC in a group of elderly volunteers and dementia patients. We used spatial homogeneity within white matter (WM) and gray matter (GM) and scan‐rescan measures as quality metrics. Results: NAVcor and PMC reduced artifacts and improved the homogeneity and reproducibility of parameter maps. In elderly participants, NAVcor improved scan‐rescan reproducibility of parameter maps (coefficient of variation decreased by 14.7% and 11.9% within WM and GM respectively). Spurious inhomogeneities within WM were reduced more in the elderly than in the young cohort (by 9% vs. 2%). PMC increased regional GM/WM contrast and was especially important in the elderly cohort, which moved twice as much as the young cohort. We did not find a significant interaction between the two corrections. Conclusion: Navigator correction and PMC significantly improved the quality of PD, R1, and R2* maps, particularly in less compliant elderly volunteers and dementia patients.