Effectiveness and safety of intravenous dexmedetomidine sedation for ophthalmic surgery under regional anesthesia. Issue 5 (September 2022)

• Record Type: Journal Article
• Authors: De Nucci, Annalisa; Scialdone, Antonio; Lando, Gabriele; Monaco, Gaspare; Cacioppo, Viviana; Campbell Davies, Sophia; Casalino, Giuseppe; Gemma, Marco
• Is Part Of: European journal of ophthalmology. Volume 32:Issue 5(2022)
• Page Start: 2598
• Page End: 2603
• Publication Date: 2022-09
• Subjects: Dexmedetomidine -- conscious sedation -- ocular surgery -- local anaesthesia; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; 617.7005
• DOI: 10.1177/11206721211059013
• Languages: English
• ISSNs: 1120-6721

Abstract

Purpose: To assess the effectiveness and safety of intravenous (IV) dexmedetomidine for sedation in ophthalmic surgery. Methods: Prospective, observational, uncontrolled, single-center study. Patients were sedated with a continuous dexmedetomidine IV infusion started 15 min before regional anesthesia administration and maintained up to the end of surgery. Effectiveness of dexmedetomidine was assessed by the Modified Observer's Assessment of Alertness and Sedation (MOAA/S) targeted at 5. Safety was assessed by the incidence of patients' movements/snoring and by the incidence of respiratory and haemodynamic complications. An eleven-point numerical rating scale (NRS) was used to assess the level of satisfaction of both the surgeon and the patient. Results: 123 patients (73 males, mean age: 63 ± 13) were included; 81 (81/123; 65.8%) patients reached the requested MOAA/S score of 5. Any intraoperative movement – mostly voluntary – occurred in 34 (34/123; 27.6%) cases with no need for a switch to general anaesthesia; no ocular complications related to the intraoperative movements occurred. Intraoperative snoring occurred in 30 (30/123; 24.4%) patients and it did not affect the surgical manoeuvres. Respiratory drive depression requiring manual or mechanical ventilation never occurred. Bradycardia occurred in 14 (14/123; 11.3%), cases but only 4 (4/123; 3.2%) patients required atropine administration, which was always effective. Intraoperative analgesia was consistently obtained and both the surgeons and the patients reported a high NRS satisfaction score. Conclusion: Dexmedetomidine provided adequate sedation in patients undergoing ocular surgery under local anaesthesia and showed a good effectiveness and safety profile. Upper airway obstruction, apnoea and snoring can occur.