Spontaneous regression of presumed ocular surface squamous neoplasia: A report of 8 cases. Issue 5 (September 2022)

• Record Type: Journal Article
• Authors: Vempuluru, Vijitha S; Ghose, Neha; Vithalani, Nidhi Mahendra; Sultana, Shahenaz; Kaliki, Swathi
• Is Part Of: European journal of ophthalmology. Volume 32:Issue 5(2022)
• Page Start: 3029
• Page End: 3034
• Publication Date: 2022-09
• Subjects: eye -- tumor -- ocular surface squamous neoplasia -- conjunctival intraepithelial neoplasia -- spontaneous regression -- spontaneous resolution; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; 617.7005
• DOI: 10.1177/11206721211057340
• Languages: English
• ISSNs: 1120-6721

Abstract

Purpose: To report the phenomenon of spontaneous regression in presumed ocular surface squamous neoplasia (OSSN) Methods: Retrospective chart review of clinically diagnosed cases of OSSN during 2016 to 2019 Results: Of the 449 OSSN lesions, spontaneous regression was seen in 8 lesions (2%). The mean age at diagnosis of OSSN was 37 years (median, 36 years; range, 21 to 59 years). All were males with unilateral, treatment-naïve tumors. Mean duration of symptoms was 3 months (median, 2 months; range, 1 to 12 months). All tumors arose within the interpalpebral region, located in the nasal quadrant in 88% (n = 7) and in temporal quadrant in 12% (n = 1). The mean tumor diameter was 4 mm (median, 4 mm; range, 3 to 5 mm). Lesions showed nodular (n = 4; 50%) or placoid (n = 4; 50%) morphology. The other features included keratin production and intrinsic vascularity (n = 8; 100%), feeder vessels (n = 4; 50%), and intratumoral pigmentation (n = 4; 50%). The diagnosis of OSSN was confirmed by classic anterior segment optical coherence tomography (AS-OCT) features. Tumors regressed after a mean period of 5 months (median, 4 months; range, <1 to 17 months) from presumed onset and a mean period of 2 months (median, 1 month; range, <1 to 6 months) from presentation to the clinic. No recurrences were noted at a mean follow up of 37 months (median, 35 months; range, 17 to 52 months) after spontaneous regression of tumors. Conclusion: OSSN can spontaneously regress in 2% of cases. Immune-mediated reversal of dysplastic changes may explain this phenomenon. Précis: In this study, spontaneous regression of presumed ocular surface squamous neoplasia was noted in 2% patients. Tumor regression resulted in restoration of normal epithelial architecture and no recurrences were observed during the follow-up period.