Changes in microglia during drug treatment of stroke. Issue 2 (22nd May 2022)

• Record Type: Journal Article
• Authors: Zhang, Ling‐Jing; Zhou, Hong‐Su; Wang, Shi‐Ya; Guan, Yi‐Huan; Zhang, Chao; Fang, De‐Rong
• Is Part Of: Ibrain. Volume 8:Issue 2(2022)
• Page Start: 227
• Page End: 240
• Publication Date: 2022-05-22
• Subjects: medicine -- microglia -- stroke; Brain; Neurosciences; Periodicals; 612.8
• DOI: 10.1002/ibra.12037
• Languages: English
• ISSNs: 2313-1934

Abstract

Abstract: Microglia are the main immune cells in the brain and the first defense barrier of the nervous system. Microglia play a complex role in the process of stroke. A growing number of studies focus on the mechanism of action of drugs functions and how to regulate microglia. Therefore, we talk about the pathophysiological mechanisms of stroke and elaborate on the microglia signaling pathways of drug action in stroke models and how these drugs play a role in stroke treatment in this review. Understanding how drugs modulate proinflammatory and anti‐inflammatory responses of microglia may be critical to implementing therapeutic strategies using immune interventions in stroke. Abstract : A growing number of studies confirm that microglia play an essential role in the occurrence and development of stroke. During the long research years, researchers have discovered that the majority of drugs used to treat stroke alleviate damage to the central nervous system by modulating signaling pathways within microglia to treat stroke.