Altered basal ganglia infraslow oscillation and resting functional connectivity in complex regional pain syndrome. Issue 7 (20th April 2022)

• Record Type: Journal Article
• Authors: Lee, Barbara; Di Pietro, Flavia; Henderson, Luke A.; Austin, Paul J.
• Is Part Of: Journal of neuroscience research. Volume 100:Issue 7(2022)
• Page Start: 1487
• Page End: 1505
• Publication Date: 2022-04-20
• Subjects: basal ganglia -- chronic pain -- complex regional pain syndrome -- infraslow oscillations -- motor dysfunction -- putamen -- resting‐state fMRI; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.25057
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract: Complex regional pain syndrome (CRPS) is a painful condition commonly accompanied by movement disturbances and often affects the upper limbs. The basal ganglia motor loop is central to movement, however, non‐motor basal ganglia loops are involved in pain, sensory integration, visual processing, cognition, and emotion. Systematic evaluation of each basal ganglia functional loop and its relation to motor and non‐motor disturbances in CRPS has not been investigated. We recruited 15 upper limb CRPS and 45 matched healthy control subjects. Using functional magnetic resonance imaging, infraslow oscillations (ISO) and resting‐state functional connectivity in motor and non‐motor basal ganglia loops were investigated using putamen and caudate seeds. Compared to controls, CRPS subjects displayed increased ISO power in the putamen contralateral to the CRPS affected limb, specifically, in contralateral putamen areas representing the supplementary motor area hand, motor hand, and motor tongue. Furthermore, compared to controls, CRPS subjects displayed increased resting connectivity between these putaminal areas as well as from the caudate body to cortical areas such as the primary motor cortex, supplementary and cingulate motor areas, parietal association areas, and the orbitofrontal cortex. These findings demonstrate changes in basal ganglia loop function in CRPS subjects and may underpin motor disturbances of CRPS. Abstract : This study is the first systematic evaluation of functional connectivity of basal ganglia motor and non‐motor territories in CRPS. In CRPS, there is increased ISOs and resting functional connectivity in motor but not in non‐motor basal ganglia territories (except caudate body functional connectivity) compared to controls.