A formal [4 + 1] cycloaddition reaction of Baylis–Hillman bromides with sulfur ylides: facile access to α-alkenyl lactones. Issue 13 (26th May 2022)

• Record Type: Journal Article
• Authors: Hua, Ting-Bi; Ma, Yu-Hong; He, Xiao-Yu; Wang, Long; Yan, Jia-Ying; Yang, Qing-Qing
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 13(2022)
• Page Start: 3558
• Page End: 3564
• Publication Date: 2022-05-26
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00451h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A formal [4 + 1] cycloaddition reaction of Baylis–Hillman adducts with sulfur ylides has been developed for the first time. Abstract : A formal [4 + 1] cycloaddition reaction of Baylis–Hillman adducts with sulfur ylides has been developed for the first time. This protocol features high functional group tolerance and provides facile access to biologically interesting α-alkenyl lactones with generally high yields. Meanwhile, the DFT calculation of the pathways has also been performed.