Review of advances in electrospinning-based strategies for spinal cord regeneration. (June 2022)

• Record Type: Journal Article
• Authors: Li, Yiran; Dong, Ting; Li, Zhiwei; Ni, Shilei; Zhou, Fang; Alimi, Olawale A; Chen, Shaojuan; Duan, Bin; Kuss, Mitchell; Wu, Shaohua
• Is Part Of: Materials today chemistry. Volume 24(2022)
• Publication Date: 2022-06
• Subjects: Electrospinning -- Cell therapy -- Drug delivery -- Electrical stimulation -- Spinal cord injury; 3D Three dimensional -- ASC activated Schwann cell -- BBB Basso-Beattie-Bresnahan -- BDNF brain-derived neurotrophic factor -- BMSC bone marrow mesenchyml stem cell -- CBD Collagen-binding domain -- CJMSC conjunctiva mesenchymal stem cell -- CNT carbon nanotube -- COL collagen -- CS chitosan -- DMSO dimethyl sulfoxide -- DRG dorsal root ganglia -- DSC decellularized spinal cord -- ECM extracellular matrix -- ELA elastin -- FGF-2 fibroblast growth factor 2 -- GDNF glial cell-derived neurotrophic factor -- Gel gelatin -- GelMA gelatin methacryloyl -- HA hyaluronic acid -- HVAC high voltage alternating current -- HVDC high voltage direct current -- IGF-1 Insulin-like growth factor-1 -- IL-1 interleukin-1 -- IL-4 interleukin-4 -- iPSC induced pluripotent stem cell -- IPT inclined plane test -- MWCNT multiwalled carbon nanotube -- NFES Near-field electrospinning -- NGF Nerve growth factor -- NSC neural stem/progenitor cell -- NTE neural tissue engineering -- OE-MSC olfactory ecto-mesenchymal stem cell -- OPC oligodendrocyte precursor cell -- PANi polyaniline -- PCL polycaprolactone -- PCU poly(carbonate urethane) -- PEDOT poly(3, 4-ethylenedioxythiophene) -- PEG poly(ethylene glycol) -- PEGDA poly(ethylene glycol) diacrylate -- PEO poly(ethylene oxide) -- PES polyethersulfone -- PGA poly(glycolic acid) -- PGS poly(glyceryl sebacate) -- PHB poly(3-hydroxybutyrate) -- PHBV poly(3-hydroxybutyrate-co-3-hydroxyvalerate) -- PLA poly(lactic acid) -- PLGA poly(lactic-co-glycolic acid) -- PLLA poly(L-lactic acid) -- PS polystyrene -- PPDO poly(p-dioxanone) -- PPy polypyrrole -- PTX paclitaxel -- PU polyurethane -- PVA poly(vinyl alcohol) -- PVDF polyvinylidene fluoride -- PVDF-TrFE polyvinylidene fluoride trifluoroethylene -- SA sodium alginate -- SCI spinal cord injury -- SDF-1α Stromal cell-derived factor-1α -- SF silk fibroin -- SJES stable jet electrospinning -- SPION superparamagnetic iron oxide nanoparticle -- SWCNT single-walled carbon nanotube -- TGFβ3 Transforming growth factor β3 -- TNF-α tumor necrosis factor-α; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2022.100944
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: Spinal cord injury (SCI) is a devastating neurological condition, commonly leading to physical and mental deficiencies, pain, other complications, and even death. Most recently, neural tissue engineering (NTE) has fostered the improvement of nerve regeneration after severe SCI, presenting a promising potential in clinic application. Ideal biomaterial scaffolds are undoubtedly the primary focus of NTE, and electrospinning technique has been extensively explored for the design and development of engineered scaffolds for NTE application owing to its simple processing, wide applicability, and huge industrialization potential. Moreover, electrospun nanofibrous scaffolds commonly possess small diameter and high specific surface area compared to traditional microfibrous scaffolds, thus providing beneficial microenvironment. Importantly, the nanofibrous structure of electrospun scaffolds largely resemble the topographic and structural characteristics of native extracellular matrix (ECM), and can effectively promote cell adhesion, growth, migration, proliferation, and even neuronal differentiation, as well as ECM remodeling and neo-tissue regeneration. In this review, we firstly introduce the anatomy of spinal cord and pathological mechanism of SCI. Then, the recent advances in the fabrication and modification of electrospun nanofibrous scaffolds for SCI treatment are summarized. Recent innovative techniques for the generation of aligned nanofibrous scaffolds and 3D anisotropic nanofibrous scaffolds are highlighted. Furthermore, several advanced synergetic approaches by integrating bioactive ingredients, external electrical or magnetic stimulation, and cell therapy with electrospun nanofibrous scaffolds are reviewed. At the end of this review, the challenges and prospects of employing electrospinning-based strategies for the SCI treatment in clinics are deeply discussed and summarized. Graphical abstract: Image 1 Highlights: A critical review on advanced electrospinning-based strategies for spinal cord regeneration application. Introducing the anatomy of spinal cord and pathological mechanism of spinal cord injury (SCI). Highlighting some innovative electrospinning-based scaffolds for SCI treatment. Summarizing some synergetic approaches with electrospun nanofibrous scaffolds. Discussing the challenges and prospects of electrospinning-based strategies for clinical SCI treatment.