Phosphate source induced rapid synthesis of urchin-like hydrated GdPO4:Eu3+ nanoparticles: Imaging and drug delivery in A549 cell line. Issue 16 (15th August 2022)

• Record Type: Journal Article
• Authors: Varaprasad, Ganji Lakshmi; Lee, Hoomin; Kim, Suheon; Kim, Eunsu; Pavitra, Eluri; Valluru, Neeraja; Han, Young-Kyu; Raju, Ganji Seeta Rama; Huh, Yun Suk
• Is Part Of: Ceramics international. Volume 48:Issue 16(2022)
• Page Start: 24063
• Page End: 24070
• Publication Date: 2022-08-15
• Subjects: Urchin-like morphology -- Photoluminescence -- A549 cells -- Bioimaging -- Drug delivery; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2022.05.086
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Energy and environmental concerns are increasing owing to the increased consumption of resources. To help solve the energy crisis and contribute to protecting our environment, this study aimed to develop a fast and eco-friendly method of synthesis. We propose a H3 PO4 assisted fast synthesis technique for developing urchin-like GdPO4 ·xH2 O:5Eu 3+ nanoparticles. First, Gd(OH)CO3 :5Eu 3+ nanospheres with sizes of about 60 nm were developed using urea-based homogeneous precipitation. These nanospheres were utilized as the Gd 3+ source and sacrificial templates in the formation of urchin-like GdPO4 .xH2 O:5Eu 3+ nanoparticles, where the Kirkendall effect takes place during hydrothermal synthesis. The structural properties confirmed the existence of the H2 O phase in the GdPO4 :5Eu 3+ nanoparticles. The synthesized urchin-like GdPO4·xH2 O:5Eu 3+ nanoparticles exhibited excellent photoluminescence in the reddish-orange region upon excitation by near-UV excitation wavelengths. These urchin-like nanoparticles demonstrated effective penetration in lung cancer cells by exhibiting luminescence from both the cytoplasm and nucleoplasm. The conjugation of doxorubicin with urchin-like GdPO4 ·xH2 O:5Eu 3+ nanoparticles helped to realize efficient antitumor activity against lung cancer.