Recent applications of CBT-Cys click reaction in biological systems. (15th August 2022)

• Record Type: Journal Article
• Authors: Zhu, Yuechao; Zhang, Xian; You, Qidong; Jiang, Zhengyu
• Is Part Of: Bioorganic & medicinal chemistry. Volume 68(2022)
• Publication Date: 2022-08-15
• Subjects: Click Chemistry -- Biorthogonal reaction -- CBT-Cys reaction -- Firefly luciferin -- Biocompatible probe -- Nanoparticles; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2022.116881
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Click chemistry is a hot topic in many research fields. A biocompatible reaction from fireflies has attracted increasing attention since 2009. Herein, we focus on the firefly-sourced click reaction between cysteine (Cys) and 2-cyanobenzothiazole (2-CBT). This reaction has many excellent properties, such as rapidity, simplicity and high selectivity, which make it successfully applied in protein labeling, molecular imaging, drug discovery and other fields. Meanwhile, its unique ability to form nanoparticles expands its applications in biological systems. We review its principle, development, and latest applications in the past 5 years and hope this review provides more profound and comprehensive insights to its further application.