A review of DICER1: structure, function and contribution to disease. Issue 7 (July 2022)

• Record Type: Journal Article
• Authors: Meiklejohn, Karleen M.; Darbinyan, Armine; Barbieri, Andrea L.
• Is Part Of: Diagnostic histopathology. Volume 28:Issue 7(2022)
• Page Start: 329
• Page End: 336
• Publication Date: 2022-07
• Subjects: DICER -- DICER syndrome -- DICER1 -- GLOW syndrome; Histology, Pathological -- Periodicals; Cytodiagnosis -- Periodicals; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; Histopathologie -- Périodiques; Pathologie -- Périodiques; Cytodiagnostics -- Périodiques; Diagnostics biologiques -- Périodiques; Histologie -- Technique -- Périodiques; Electronic journals; 616.07582
• DOI: 10.1016/j.mpdhp.2022.05.004
• Languages: English
• ISSNs: 1756-2317

Abstract

Abstract: DICER1 is an important housekeeping gene that encodes a multi-domain enzyme that functions in small RNA processing. The enzymatic products function in several pathways including RNA interference, DNA damage repair and antiviral response. At the protein level, endoribonuclease DICER also plays a role in many human illnesses, and much research is being done to clarify the full spectrum of its functions and relation to neoplastic and non-neoplastic disease. Both somatic and germline mutations in DICER1 have been identified, and germline mutations have been associated with at least two named syndromes: DICER1 syndrome and GLOW syndrome. The ubiquitous nature of this enzyme makes it an attractive target for future study and therapeutic potential, but much remains to be learned.