Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus. (1st July 2022)

• Record Type: Journal Article
• Authors: Chen, Lu; Zhu, Lin; Xu, Jing; Xu, Puying; Han, Yanbing; Chang, Lvhua; Wu, Qian
• Is Part Of: Neuroscience. Volume 494(2022)
• Page Start: 69
• Page End: 81
• Publication Date: 2022-07-01
• Subjects: AP action potential -- BLBP brain lipid-binding protein -- BrdU bromodeoxyuridine -- DG dentate gyrus -- DISC1 disrupted in Schizophrenia 1 -- ERK extracellular signal-regulated kinase -- GCL granulosa cell layer -- GFAP glial fibrillary acidic protein -- GSK3β glycogen synthase kinase 3 beta -- HEGCs hilar ectopic granule cells -- NDEL1 nuclear distribution factor E homolog like 1 -- NSCs neural stem cells -- RGCs radial glial cells -- RTLE refractory temporal lobe epilepsy -- SE status epilepticus -- SGZ subgranular zone -- TLE temporal lobe epilepsy; status epilepticus -- DISC1 -- neurogenesis -- hilus; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2022.05.009
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: DISC1 expression was significantly down-regulated in the hilus after SE. In the hilus, DISC1 might regulate ectopic neurogenesis in pilocarpine-induced SE. The cell "encircling" indicated close relationship between DISC1 and astrocytes. Abstract: Augmentation of neurogenesis and migration of newly born neurons into ectopic regions like the hilus play critical roles during the pathophysiology of acute kindled seizures. Evidence shows that disrupted in schizophrenia 1 (DISC1) has an influence on adult neurogenesis in the dentate gyrus (DG); however, its role of regulating neurogenesis and mispositioned newborn neurons in the hilus after status epilepticus (SE) remains unknown. Using double immunofluorescence staining, the present study clarifies that DISC1 is co-expressed with nearly all of the neuronal markers, which are characterized by different stages of neuronal development, after pilocarpine-induced SE in mice. This reveals that DISC1 takes part in the modulation of neurogenesis in the hilus post-SE. Unexpectedly, an interesting phenomenon was observed as well. Some glial fibrillary acidic protein (GFAP)-positive cells in the hilus appeared to encircle the DISC1-positive cells, which possibly indicated that DISC1 may participate in the process of neuronal or neural development associated with astrocytes such as phagocytosis, dendritic spine development, synaptic transmission, and developmental and synaptic plasticity.